biostudies-literatureBoss MKNCATS NIH HHSBoehringer IngelheimCollege of Veterinary Medicine and Biomedical Sciences, Colorado State UniversityNational Institutes of HealthNIH HHS1033704https://www.ebi.ac.uk/biostudies/studies/S-EPMC9868558biostudies-literatureUnknown12<h4>Introduction</h4>Improving outcomes for oral squamous cell carcinoma (OSCC) patients has been hindered by a lack of effective predictive animal models. Spontaneously occurring canine OSCC could help fill this gap. The objective of this study was to characterize the immune landscape of canine OSCC to advance understanding of how dogs could serve as a surrogate for human OSCC.<h4>Methods/results</h4>Canine OSCC contains a heterogenous tumor immune microenvironment. CD3+ T cells were the predominant tumor infiltrating immune cell population; however, there was a wide range CD3+ T cell density across samples. The most common CD3+ T cell micro-anatomical distribution was defined as "pre-existing immunity", but the remaining 20% of tumors were characterized as "immunologically ignorant" or "Frontiers in oncologyCanine oral squamous cell carcinoma as a spontaneous, translational model for radiation and immunology research.PMC9868558K01 OD031809K01 OD022982K01 OD022982, L30 TR002126, K01 OD031809L30 TR002126Harrison LGGold ARegan DPBoss MKKaram SDfalseCanine oral squamous cell carcinoma as a spontaneous, translational model for radiation and immunology research.<h4>Introduction</h4>Improving outcomes for oral squamous cell carcinoma (OSCC) patients has been hindered by a lack of effective predictive animal models. Spontaneously occurring canine OSCC could help fill this gap. The objective of this study was to characterize the immune landscape of canine OSCC to advance understanding of how dogs could serve as a surrogate for human OSCC.<h4>Methods/results</h4>Canine OSCC contains a heterogenous tumor immune microenvironment. CD3+ T cells were the predominant tumor infiltrating immune cell population; however, there was a wide range CD3+ T cell density across samples. The most common CD3+ T cell micro-anatomical distribution was defined as "pre-existing immunity", but the remaining 20% of tumors were characterized as "immunologically ignorant" or "2022-01-01T00:00:00Z20222026-07-14T21:16:59.67Z2025-04-06T11:11:50.536ZS-EPMC98685583669839810.3389/fonc.2022.1033704