{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Chen PK"],"pubmed_abstract":["<h4>Objective</h4>Neutralizing anti-interferon (IFN)-γ autoantibodies are linked to opportunistic infections (OIs). To explore the association between anti-IFN-γ autoantibodies and OIs in patients with adult-onset Still's disease (AOSD), we aimed to examine the ability of these autoantibodies to blockade signal transducer and activator of transcription (STAT1)-phosphorylation and chemokines production.<h4>Methods</h4>Serum titers of anti-IFN-γ autoantibodies were quantified using ELISA in 29 AOSD and 22 healthy controls (HC). The detectable autoantibodies were verified with immunoblotting assay, and their neutralizing capacity against IFN-γ-signaling was evaluated with flow-cytometry analysis and immunoblotting. IFN-γ-mediated production of supernatant chemokines, including monocyte chemoa"],"journal":["Frontiers in medicine"],"pagination":["1097514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9868624"],"repository":["biostudies-literature"],"pubmed_title":["High-titer anti-interferon-γ neutralizing autoantibodies linked to opportunistic infections in patients with adult-onset still's disease."],"pmcid":["PMC9868624"],"pubmed_authors":["Chou CH","Chen PK","Chang SH","Chen DY","Liao TL","Yeo KJ"],"additional_accession":[]},"is_claimable":false,"name":"High-titer anti-interferon-γ neutralizing autoantibodies linked to opportunistic infections in patients with adult-onset still's disease.","description":"<h4>Objective</h4>Neutralizing anti-interferon (IFN)-γ autoantibodies are linked to opportunistic infections (OIs). To explore the association between anti-IFN-γ autoantibodies and OIs in patients with adult-onset Still's disease (AOSD), we aimed to examine the ability of these autoantibodies to blockade signal transducer and activator of transcription (STAT1)-phosphorylation and chemokines production.<h4>Methods</h4>Serum titers of anti-IFN-γ autoantibodies were quantified using ELISA in 29 AOSD and 22 healthy controls (HC). The detectable autoantibodies were verified with immunoblotting assay, and their neutralizing capacity against IFN-γ-signaling was evaluated with flow-cytometry analysis and immunoblotting. IFN-γ-mediated production of supernatant chemokines, including monocyte chemoa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:47:40.132Z","creation":"2025-04-04T19:47:40.132Z"},"accession":"S-EPMC9868624","cross_references":{"pubmed":["36698819"],"doi":["10.3389/fmed.2022.1097514"]}}