{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Yao S"],"pubmed_abstract":["<h4>Introduction</h4>Digestive system pan-cancer is one of the lethal malignant tumors, which have the propensity for poor prognosis and difficult treatment. Endoplasmic reticulum (ER) stress has served as a pivotal role in the progression of the tumor, while the implication of ER stress on digestive system pan-cancers still needs elucidation, especially from the perspective of clinical outcome and that of genomic features.<h4>Methods</h4>First, Among the ER STRESS factors from the REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR (113 genes) and HALLMARK_UNFOLDED_PROTEIN_RESPONSE (92 genes) terms, 153 ER STRESS regulators were identified after removing replicates. The somatic mutation data and copy number variation data of gastrointestinal pan-cancer were downloaded from The Cancer Genome Atlas (TCG"],"journal":["Frontiers in oncology"],"pagination":["1072576"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9868864"],"repository":["biostudies-literature"],"pubmed_title":["Genomic and clinical features of endoplasmic reticulum stress factor in digestive system pan-cancer studies."],"pmcid":["PMC9868864"],"pubmed_authors":["Xu L","Pan X","Yao S","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Genomic and clinical features of endoplasmic reticulum stress factor in digestive system pan-cancer studies.","description":"<h4>Introduction</h4>Digestive system pan-cancer is one of the lethal malignant tumors, which have the propensity for poor prognosis and difficult treatment. Endoplasmic reticulum (ER) stress has served as a pivotal role in the progression of the tumor, while the implication of ER stress on digestive system pan-cancers still needs elucidation, especially from the perspective of clinical outcome and that of genomic features.<h4>Methods</h4>First, Among the ER STRESS factors from the REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR (113 genes) and HALLMARK_UNFOLDED_PROTEIN_RESPONSE (92 genes) terms, 153 ER STRESS regulators were identified after removing replicates. The somatic mutation data and copy number variation data of gastrointestinal pan-cancer were downloaded from The Cancer Genome Atlas (TCG","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T12:06:23.532Z","creation":"2025-04-04T03:42:27.686Z"},"accession":"S-EPMC9868864","cross_references":{"pubmed":["36698399"],"doi":["10.3389/fonc.2022.1072576"]}}