biostudies-literatureUnknown12Yao S<h4>Introduction</h4>Digestive system pan-cancer is one of the lethal malignant tumors, which have the propensity for poor prognosis and difficult treatment. Endoplasmic reticulum (ER) stress has served as a pivotal role in the progression of the tumor, while the implication of ER stress on digestive system pan-cancers still needs elucidation, especially from the perspective of clinical outcome and that of genomic features.<h4>Methods</h4>First, Among the ER STRESS factors from the REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR (113 genes) and HALLMARK_UNFOLDED_PROTEIN_RESPONSE (92 genes) terms, 153 ER STRESS regulators were identified after removing replicates. The somatic mutation data and copy number variation data of gastrointestinal pan-cancer were downloaded from The Cancer Genome Atlas (TCGFrontiers in oncology1072576https://www.ebi.ac.uk/biostudies/studies/S-EPMC9868864biostudies-literatureGenomic and clinical features of endoplasmic reticulum stress factor in digestive system pan-cancer studies.PMC9868864Xu LPan XYao SYu YfalseGenomic and clinical features of endoplasmic reticulum stress factor in digestive system pan-cancer studies.<h4>Introduction</h4>Digestive system pan-cancer is one of the lethal malignant tumors, which have the propensity for poor prognosis and difficult treatment. Endoplasmic reticulum (ER) stress has served as a pivotal role in the progression of the tumor, while the implication of ER stress on digestive system pan-cancers still needs elucidation, especially from the perspective of clinical outcome and that of genomic features.<h4>Methods</h4>First, Among the ER STRESS factors from the REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR (113 genes) and HALLMARK_UNFOLDED_PROTEIN_RESPONSE (92 genes) terms, 153 ER STRESS regulators were identified after removing replicates. The somatic mutation data and copy number variation data of gastrointestinal pan-cancer were downloaded from The Cancer Genome Atlas (TCG2022-01-01T00:00:00Z20222026-04-08T12:06:23.532Z2025-04-04T03:42:27.686ZS-EPMC98688643669839910.3389/fonc.2022.1072576