{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liaqat A"],"funding":["Chinese Government Scholarship","China Postdoctoral Science Foundation","National Natural Science Foundation of China","CAS-TWAS President’s Fellowship"],"pagination":["49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9869573"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Salt stress significantly influences plant growth and reduces crop yield. It is highly anticipated to develop salt-tolerant crops with salt tolerance genes and transgenic technology. Hence, it is critical to identify salt tolerance genes that can be used to improve crop salt tolerance.<h4>Results</h4>We report that the transcription elongation factor suppressor of Ty 4-2 (SPT4-2) is a positive modulator of salt tolerance in Arabidopsis thaliana. AtSPT4-2 expression is induced by salt stress. Knockout mutants of AtSPT4-2 display a salt-sensitive phenotype, whereas AtSPT4-2 overexpression lines exhibit enhanced salt tolerance. Comparative transcriptomic analyses revealed that AtSPT4-2 may orchestrate the expression of genes associated with salt tolerance, including stress-responsive markers, protein kinases and phosphatases, salt-responsive transcription factors and those maintaining ion homeostasis, suggesting that AtSPT4-2 improves salt tolerance mainly by maintaining ion homeostasis and enhancing stress tolerance.<h4>Conclusions</h4>AtSPT4-2 positively modulates salt tolerance by maintaining ion homeostasis and regulating stress-responsive genes and serves as a candidate for the improvement of crop salt tolerance."],"journal":["BMC plant biology"],"pubmed_title":["Transcription elongation factor AtSPT4-2 positively modulates salt tolerance in Arabidopsis thaliana."],"pmcid":["PMC9869573"],"funding_grant_id":["2020T130634","31900230"],"pubmed_authors":["Sun L","Liaqat A","Zhao P","Xiang C","Alfatih A","Jan SU"],"additional_accession":[]},"is_claimable":false,"name":"Transcription elongation factor AtSPT4-2 positively modulates salt tolerance in Arabidopsis thaliana.","description":"<h4>Background</h4>Salt stress significantly influences plant growth and reduces crop yield. It is highly anticipated to develop salt-tolerant crops with salt tolerance genes and transgenic technology. Hence, it is critical to identify salt tolerance genes that can be used to improve crop salt tolerance.<h4>Results</h4>We report that the transcription elongation factor suppressor of Ty 4-2 (SPT4-2) is a positive modulator of salt tolerance in Arabidopsis thaliana. AtSPT4-2 expression is induced by salt stress. Knockout mutants of AtSPT4-2 display a salt-sensitive phenotype, whereas AtSPT4-2 overexpression lines exhibit enhanced salt tolerance. Comparative transcriptomic analyses revealed that AtSPT4-2 may orchestrate the expression of genes associated with salt tolerance, including stress-responsive markers, protein kinases and phosphatases, salt-responsive transcription factors and those maintaining ion homeostasis, suggesting that AtSPT4-2 improves salt tolerance mainly by maintaining ion homeostasis and enhancing stress tolerance.<h4>Conclusions</h4>AtSPT4-2 positively modulates salt tolerance by maintaining ion homeostasis and regulating stress-responsive genes and serves as a candidate for the improvement of crop salt tolerance.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T17:23:21.825Z","creation":"2025-02-19T03:00:16.107Z"},"accession":"S-EPMC9869573","cross_references":{"pubmed":["36683032"],"doi":["10.1186/s12870-023-04060-x"]}}