{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ries A"],"funding":["Berndorf Private Foundation","Austrian Science Fund FWF","Hungarian National Research, Development and Innovation Office","City of Vienna Fund for Innovative Interdisciplinary Cancer Research"],"pagination":["27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9869633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(1)"],"pubmed_abstract":["Background
Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, PM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supply of stimulating signals by cells of the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are an abundant cell type of the TME and have been shown to drive the progression of several malignancies. The aim of the current study was to isolate and characterize patient-derived mesothelioma-associated fibroblasts (Meso-CAFs), and evaluate their impact on PM cells.Methods
Meso-CAFs were isolated from surgical specimens of PM patients and analyzed by array comparative genomic hybrid"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin."],"pmcid":["PMC9869633"],"funding_grant_id":["I 3977","KH130356, KKP126790, 2020-1.1.6-JÖVŐ, TKP2021-EGA-33","I 4677","I 3522","21132","T 1062","FWF I3522","FWF I4677","FWF T 1062-B33","FWF I3977"],"pubmed_authors":["Ries A","Mader JC","Dolznig H","Gerner C","Hoda MA","Schelch K","Pirker C","Mosleh B","Slany A","Mullauer L","Mohr T","Krupitza G","Flehberger D","Grusch M","Berger W","Sinn K","Dome B"],"additional_accession":[]},"is_claimable":false,"name":"Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin.","description":"Background
Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, PM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supply of stimulating signals by cells of the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are an abundant cell type of the TME and have been shown to drive the progression of several malignancies. The aim of the current study was to isolate and characterize patient-derived mesothelioma-associated fibroblasts (Meso-CAFs), and evaluate their impact on PM cells.Methods
Meso-CAFs were isolated from surgical specimens of PM patients and analyzed by array comparative genomic hybrid","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-27T22:45:12.268Z","creation":"2025-04-04T13:08:08.643Z"},"accession":"S-EPMC9869633","cross_references":{"pubmed":["36683050"],"doi":["10.1186/s13046-022-02582-0"]}}