{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kronzer VL"],"funding":["NIA NIH HHS","NIAMS NIH HHS"],"pagination":["152100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9869704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57"],"pubmed_abstract":["<h4>Objective</h4>We aimed to determine the association of physical activity and dietary factors on RA risk.<h4>Methods</h4>This case-control study within the Mayo Clinic Biobank matched incident RA cases (two codes plus disease-modifying anti-rheumatic drug, PPV 95%) to controls 1:3 on age, sex, and recruitment year/location. A baseline questionnaire assessed activity and dietary exposures. Logistic regression models calculated adjusted odds ratios (aOR) with 95% confidence intervals (CI) of RA for each of 45 activity/dietary exposures.<h4>Results</h4>We identified 212 incident RA cases and 636 controls (mean age 64, 70% female). Active work physical activity was associated with elevated risk of RA (aOR 3.00, 95% CI 1.58-5.69 vs. sedentary); leisure activity was not (aOR 0.96, 95% CI 0.64-1.42 sedentary vs. active). Three or more servings high-fat food and 5+ servings fruits/vegetables daily showed non-significant associations with RA (aOR 1.22, 95% CI 0.74-2.00 vs. 0-1 time; aOR 0.75, 95% CI 0.51-1.11 vs. 0-3 times), especially in sensitivity analyses with at least five years between questionnaire and RA (aOR 1.80, 95% CI 0.69-4.71; aOR 0.54, 95% CI 0.27-1.08). Alcohol binging was not associated with RA risk (aOR 1.28, 95% CI 0.56-2.96). Finally, sensitivity (versus primary) analyses showed a nonsignificant increase in RA risk for most vitamins and supplements.<h4>Conclusion</h4>Active work physical activity and some nutritional profiles (increased high-fat, reduced fruit/vegetable consumption) may be associated with increased risk of RA. Confirmatory studies are needed."],"journal":["Seminars in arthritis and rheumatism"],"pubmed_title":["Association between work physical activity, dietary factors, and risk of rheumatoid arthritis."],"pmcid":["PMC9869704"],"funding_grant_id":["R01 AR077607","K24 AG078179","P30 AR072577","R01 AR046849","P30 AR070253","R01 AG068192"],"pubmed_authors":["Sparks JA","Crowson CS","Davis JM","Kronzer VL","Myasoedova E","Lennon RJ"],"additional_accession":[]},"is_claimable":false,"name":"Association between work physical activity, dietary factors, and risk of rheumatoid arthritis.","description":"<h4>Objective</h4>We aimed to determine the association of physical activity and dietary factors on RA risk.<h4>Methods</h4>This case-control study within the Mayo Clinic Biobank matched incident RA cases (two codes plus disease-modifying anti-rheumatic drug, PPV 95%) to controls 1:3 on age, sex, and recruitment year/location. A baseline questionnaire assessed activity and dietary exposures. Logistic regression models calculated adjusted odds ratios (aOR) with 95% confidence intervals (CI) of RA for each of 45 activity/dietary exposures.<h4>Results</h4>We identified 212 incident RA cases and 636 controls (mean age 64, 70% female). Active work physical activity was associated with elevated risk of RA (aOR 3.00, 95% CI 1.58-5.69 vs. sedentary); leisure activity was not (aOR 0.96, 95% CI 0.64-1.42 sedentary vs. active). Three or more servings high-fat food and 5+ servings fruits/vegetables daily showed non-significant associations with RA (aOR 1.22, 95% CI 0.74-2.00 vs. 0-1 time; aOR 0.75, 95% CI 0.51-1.11 vs. 0-3 times), especially in sensitivity analyses with at least five years between questionnaire and RA (aOR 1.80, 95% CI 0.69-4.71; aOR 0.54, 95% CI 0.27-1.08). Alcohol binging was not associated with RA risk (aOR 1.28, 95% CI 0.56-2.96). Finally, sensitivity (versus primary) analyses showed a nonsignificant increase in RA risk for most vitamins and supplements.<h4>Conclusion</h4>Active work physical activity and some nutritional profiles (increased high-fat, reduced fruit/vegetable consumption) may be associated with increased risk of RA. Confirmatory studies are needed.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T12:10:08.518Z","creation":"2025-04-05T12:10:08.518Z"},"accession":"S-EPMC9869704","cross_references":{"pubmed":["36166875"],"doi":["10.1016/j.semarthrit.2022.152100"]}}