{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hernandez JR"],"funding":["Western Gulf Center of Excellence for Vector-Borne Diseases","USDA-NIFA","ACL HHS","Texas A&M AgriLife Research Insect Vector Diseases Grant Program"],"pagination":["e0011033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9870149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Harris County, TX, is the third most populous county in the USA and upon detection of arboviruses Harris County Public Health applies insecticides (e.g., pyrethroid-based Permanone 31-66) against adults of Culex quinquefasciatus to prevent disease transmission. Populations of Aedes aegypti, while not yet a target of public health control, are likely affected by pyrethroid exposure. As this species is a vector of emerging arboviruses, its resistance status to Permanone and the kdr mutations in the voltage-gated sodium channel (VGSC) associated with pyrethroid resistance were investigated. We examined females of known genotype at the V1016I and F1534C sites (N = 716) for their genotype at the 410 amino acid position in the VGSC, and for the influence of their kdr genotype on survival to Perm"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Impact of the V410L kdr mutation and co-occurring genotypes at kdr sites 1016 and 1534 in the VGSC on the probability of survival of the mosquito Aedes aegypti (L.) to Permanone in Harris County, TX, USA."],"pmcid":["PMC9870149"],"funding_grant_id":["124196-77110","1U01CK000512","U01CK000512","TEX0-2-9206"],"pubmed_authors":["Fredregill CL","Liu S","Pietrantonio PV","Hernandez JR"],"additional_accession":[]},"is_claimable":false,"name":"Impact of the V410L kdr mutation and co-occurring genotypes at kdr sites 1016 and 1534 in the VGSC on the probability of survival of the mosquito Aedes aegypti (L.) to Permanone in Harris County, TX, USA.","description":"Harris County, TX, is the third most populous county in the USA and upon detection of arboviruses Harris County Public Health applies insecticides (e.g., pyrethroid-based Permanone 31-66) against adults of Culex quinquefasciatus to prevent disease transmission. Populations of Aedes aegypti, while not yet a target of public health control, are likely affected by pyrethroid exposure. As this species is a vector of emerging arboviruses, its resistance status to Permanone and the kdr mutations in the voltage-gated sodium channel (VGSC) associated with pyrethroid resistance were investigated. We examined females of known genotype at the V1016I and F1534C sites (N = 716) for their genotype at the 410 amino acid position in the VGSC, and for the influence of their kdr genotype on survival to Perm","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T13:07:54.818Z","creation":"2025-04-04T13:07:54.818Z"},"accession":"S-EPMC9870149","cross_references":{"pubmed":["36689414"],"doi":["10.1371/journal.pntd.0011033"]}}