{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berger DC"],"funding":["Stiftung für Forschung in Anästhesiologie und Intensivmedizin","Fondation Johanna Dürmüller-Bol"],"pagination":["L102-L113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9870575"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["324(2)"],"pubmed_abstract":["Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principle under conditions such as dead space and shunt in 13 anesthetized swine undergoing centrally cannulated veno-arterial extracorporeal membrane oxygenation (V-A ECMO, 308 measurement periods) therapy. We assumed that the ratio of carbon dioxide elimination (V̇co<sub>2</sub>) or oxygen uptake (V̇o<sub>2</sub>) between the membrane and native lung corresponds to the ratio of respective blood flows. Unequal ventilation/perfusion (V̇/Q̇) ratios were corrected towards unity. Pulmonary blood flow was calculated and compared to an ultrasonic flow probe on the pulmonary artery with a bias of 99 mL/min (limits of agreement -542 to 741 mL/min) with blood content V̇o<sub>2</sub> an"],"journal":["American journal of physiology. Lung cellular and molecular physiology"],"pubmed_title":["Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model."],"pmcid":["PMC9870575"],"funding_grant_id":["26/2018","481"],"pubmed_authors":["Nettelbeck K","Zwicker L","Casoni D","Berger DC","Heinisch PP","Haenggi M","Gattinoni L","Bachmann KF","Jenni H"],"additional_accession":[]},"is_claimable":false,"name":"Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model.","description":"Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principle under conditions such as dead space and shunt in 13 anesthetized swine undergoing centrally cannulated veno-arterial extracorporeal membrane oxygenation (V-A ECMO, 308 measurement periods) therapy. We assumed that the ratio of carbon dioxide elimination (V̇co<sub>2</sub>) or oxygen uptake (V̇o<sub>2</sub>) between the membrane and native lung corresponds to the ratio of respective blood flows. Unequal ventilation/perfusion (V̇/Q̇) ratios were corrected towards unity. Pulmonary blood flow was calculated and compared to an ultrasonic flow probe on the pulmonary artery with a bias of 99 mL/min (limits of agreement -542 to 741 mL/min) with blood content V̇o<sub>2</sub> an","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T20:52:16.358Z","creation":"2024-11-20T20:32:26.369Z"},"accession":"S-EPMC9870575","cross_references":{"pubmed":["36511508"],"doi":["10.1152/ajplung.00045.2022"]}}