biostudies-literatureBerger DCStiftung für Forschung in Anästhesiologie und IntensivmedizinFondation Johanna Dürmüller-BolL102-L113https://www.ebi.ac.uk/biostudies/studies/S-EPMC9870575biostudies-literatureUnknown324(2)Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principle under conditions such as dead space and shunt in 13 anesthetized swine undergoing centrally cannulated veno-arterial extracorporeal membrane oxygenation (V-A ECMO, 308 measurement periods) therapy. We assumed that the ratio of carbon dioxide elimination (V̇co₂) or oxygen uptake (V̇o₂) between the membrane and native lung corresponds to the ratio of respective blood flows. Unequal ventilation/perfusion (V̇/Q̇) ratios were corrected towards unity. Pulmonary blood flow was calculated and compared to an ultrasonic flow probe on the pulmonary artery with a bias of 99 mL/min (limits of agreement -542 to 741 mL/min) with blood content V̇o₂ anAmerican journal of physiology. Lung cellular and molecular physiologyIntegral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model.PMC987057526/2018481Nettelbeck KZwicker LCasoni DBerger DCHeinisch PPHaenggi MGattinoni LBachmann KFJenni HfalseIntegral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model.Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principle under conditions such as dead space and shunt in 13 anesthetized swine undergoing centrally cannulated veno-arterial extracorporeal membrane oxygenation (V-A ECMO, 308 measurement periods) therapy. We assumed that the ratio of carbon dioxide elimination (V̇co₂) or oxygen uptake (V̇o₂) between the membrane and native lung corresponds to the ratio of respective blood flows. Unequal ventilation/perfusion (V̇/Q̇) ratios were corrected towards unity. Pulmonary blood flow was calculated and compared to an ultrasonic flow probe on the pulmonary artery with a bias of 99 mL/min (limits of agreement -542 to 741 mL/min) with blood content V̇o₂ an2023-01-01T00:00:00Z2023 Feb2025-04-04T20:52:16.358Z2024-11-20T20:32:26.369ZS-EPMC98705753651150810.1152/ajplung.00045.2022