biostudies-literatureSchroeter MLLeipzig Research Center for Civilization DiseasesDeutsche ForschungsgemeinschaftMax Planck Institute for Human Cognitive and Brain SciencesSächsische Aufbaubank1236https://www.ebi.ac.uk/biostudies/studies/S-EPMC9870947biostudies-literatureUnknown13(1)Aging increases the risk to develop Alzheimer's disease. Cardiovascular diseases might accelerate this process. Our study aimed at investigating the impact of heart failure on brain connectivity using functional magnetic resonance imaging at resting state. Here we show brain connectivity alterations related to heart failure and cognitive performance. Heart failure decreases brain connectivity in the precuneus. Precuneus dysconnectivity was associated with biomarkers of heart failure-left ventricular ejection fraction and N-terminal prohormone of brain natriuretic peptide-and cognitive performance, predominantly executive function. Meta-analytical data-mining approaches-conducted in the BrainMap and Neurosynth databases-revealed that social and executive cognitive functions are mainly assocScientific reportsHeart failure decouples the precuneus in interaction with social cognition and executive functions.PMC9870947CRC 1052SCHR 774/5-1eHealthSax InitiativeTeren ACamilleri JMueller KGodulla JEickhoff SSchroeter MLThiel FVillringer ABeutner FDubovoy VKTaskin BfalseHeart failure decouples the precuneus in interaction with social cognition and executive functions.Aging increases the risk to develop Alzheimer's disease. Cardiovascular diseases might accelerate this process. Our study aimed at investigating the impact of heart failure on brain connectivity using functional magnetic resonance imaging at resting state. Here we show brain connectivity alterations related to heart failure and cognitive performance. Heart failure decreases brain connectivity in the precuneus. Precuneus dysconnectivity was associated with biomarkers of heart failure-left ventricular ejection fraction and N-terminal prohormone of brain natriuretic peptide-and cognitive performance, predominantly executive function. Meta-analytical data-mining approaches-conducted in the BrainMap and Neurosynth databases-revealed that social and executive cognitive functions are mainly assoc2023-01-01T00:00:00Z2023 Jan2026-03-31T10:38:54.342Z2025-04-04T18:53:17.267ZS-EPMC98709473669072310.1038/s41598-023-28338-0