{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Whedon SD"],"funding":["American Cancer Society","National Institutes of Health","AbbVie","NIGMS NIH HHS","NIGMS","Leukemia and Lymphoma Society"],"pagination":["102255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9870960"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72"],"pubmed_abstract":["Lysine acetyltransferase (KAT) enzymes including the p300, MYST, and GCN5 families play major roles in modulating the structure of chromatin and regulating transcription. Because of their dysregulation in various disease states including cancer, efforts to develop inhibitors of KATs have steadily gained momentum. Here we provide an overview of recent progress on the development of high quality chemical probes of the p300 and MYST family of KATs and how they are emerging as useful tools for basic and translational investigation."],"journal":["Current opinion in chemical biology"],"pubmed_title":["KATs off: Biomedical insights from lysine acetyltransferase inhibitors."],"pmcid":["PMC9870960"],"funding_grant_id":["R37 GM062437","R35 GM149229","GM62437","PF-20-105-01-DMC","R01 GM062437"],"pubmed_authors":["Whedon SD","Cole PA"],"additional_accession":[]},"is_claimable":false,"name":"KATs off: Biomedical insights from lysine acetyltransferase inhibitors.","description":"Lysine acetyltransferase (KAT) enzymes including the p300, MYST, and GCN5 families play major roles in modulating the structure of chromatin and regulating transcription. Because of their dysregulation in various disease states including cancer, efforts to develop inhibitors of KATs have steadily gained momentum. Here we provide an overview of recent progress on the development of high quality chemical probes of the p300 and MYST family of KATs and how they are emerging as useful tools for basic and translational investigation.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T11:56:10.636Z","creation":"2025-02-19T04:59:49.74Z"},"accession":"S-EPMC9870960","cross_references":{"pubmed":["36584580"],"doi":["10.1016/j.cbpa.2022.102255"]}}