{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ono M"],"funding":["Japan Society for the Promotion of Science"],"pagination":["9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Purpose</h4>Wasabi is a traditional plant seasoning with an anti-septic function. Recent studies revealed several functions of Wasabi, such as anti-inflammation; however, the anti-tumor effect against endometrial carcinoma (EMC) cells has not been examined. In the present study, we investigated the anti-tumor effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), a major chemical compound of Wasabi, against various EMC cell lines in vitro and in vivo.<h4>Methods</h4>The effect of 6-MITC on cell viability was measured by the WST-1 assay in EMC and HUVEC cells. The impact of 6-MITC oral administration in nude mice was measured to assess the growth of the EMC xenograft and natural killer (NK) cell activity in the spleen.<h4>Results</h4>The addition of 6-MITC suppressed the proliferat"],"journal":["Discover. Oncology"],"pubmed_title":["Anti-tumor effect of Wasabi component, 6-(methylsulfinyl) hexyl isothiocyanate, against endometrial carcinoma cells."],"pmcid":["PMC9871149"],"funding_grant_id":["21K09537"],"pubmed_authors":["Ono M","Tanaka Y","Miyamoto T","Shinagawa M","Ando H","Yokokawa Y","Shiozawa T","Takeuchi H","Fuseya C","Asaka R","Horiuchi A"],"additional_accession":[]},"is_claimable":false,"name":"Anti-tumor effect of Wasabi component, 6-(methylsulfinyl) hexyl isothiocyanate, against endometrial carcinoma cells.","description":"<h4>Purpose</h4>Wasabi is a traditional plant seasoning with an anti-septic function. Recent studies revealed several functions of Wasabi, such as anti-inflammation; however, the anti-tumor effect against endometrial carcinoma (EMC) cells has not been examined. In the present study, we investigated the anti-tumor effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), a major chemical compound of Wasabi, against various EMC cell lines in vitro and in vivo.<h4>Methods</h4>The effect of 6-MITC on cell viability was measured by the WST-1 assay in EMC and HUVEC cells. The impact of 6-MITC oral administration in nude mice was measured to assess the growth of the EMC xenograft and natural killer (NK) cell activity in the spleen.<h4>Results</h4>The addition of 6-MITC suppressed the proliferat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-06-01T01:36:59.54Z","creation":"2024-11-14T06:12:48.197Z"},"accession":"S-EPMC9871149","cross_references":{"pubmed":["36689027"],"doi":["10.1007/s12672-023-00617-2"]}}