biostudies-literatureOno MJapan Society for the Promotion of Science9https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871149biostudies-literatureUnknown14(1)<h4>Purpose</h4>Wasabi is a traditional plant seasoning with an anti-septic function. Recent studies revealed several functions of Wasabi, such as anti-inflammation; however, the anti-tumor effect against endometrial carcinoma (EMC) cells has not been examined. In the present study, we investigated the anti-tumor effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), a major chemical compound of Wasabi, against various EMC cell lines in vitro and in vivo.<h4>Methods</h4>The effect of 6-MITC on cell viability was measured by the WST-1 assay in EMC and HUVEC cells. The impact of 6-MITC oral administration in nude mice was measured to assess the growth of the EMC xenograft and natural killer (NK) cell activity in the spleen.<h4>Results</h4>The addition of 6-MITC suppressed the proliferatDiscover. OncologyAnti-tumor effect of Wasabi component, 6-(methylsulfinyl) hexyl isothiocyanate, against endometrial carcinoma cells.PMC987114921K09537Ono MTanaka YMiyamoto TShinagawa MAndo HYokokawa YShiozawa TTakeuchi HFuseya CAsaka RHoriuchi AfalseAnti-tumor effect of Wasabi component, 6-(methylsulfinyl) hexyl isothiocyanate, against endometrial carcinoma cells.<h4>Purpose</h4>Wasabi is a traditional plant seasoning with an anti-septic function. Recent studies revealed several functions of Wasabi, such as anti-inflammation; however, the anti-tumor effect against endometrial carcinoma (EMC) cells has not been examined. In the present study, we investigated the anti-tumor effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), a major chemical compound of Wasabi, against various EMC cell lines in vitro and in vivo.<h4>Methods</h4>The effect of 6-MITC on cell viability was measured by the WST-1 assay in EMC and HUVEC cells. The impact of 6-MITC oral administration in nude mice was measured to assess the growth of the EMC xenograft and natural killer (NK) cell activity in the spleen.<h4>Results</h4>The addition of 6-MITC suppressed the proliferat2023-01-01T00:00:00Z2023 Jan2025-06-01T01:36:59.54Z2024-11-14T06:12:48.197ZS-EPMC98711493668902710.1007/s12672-023-00617-2