{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Qin C"],"pubmed_abstract":["<b>Background:</b> Growing evidence has supported that chronic psychological stress would cause heart damage, However the mechanisms involved are not clear and effective interventions are insufficient. Cannabinoid type 2 receptor (CB2R) can be a potential treatment for cardiac injury. This study is aimed to investigate the protective mechanism of CB2R agonist against chronic psychological stress-induced cardiac injury. <b>Methods:</b> A mouse chronic psychological stress model was constructed based on a chronic unpredictable stress pattern. Mice were performed a three-week psychological stress procedure, and cardiac tissues of them were collected for whole-transcriptome sequencing. Overlap analysis was performed on differentially expressed mRNAs (DE-mRNAs) and ER stress-related genes (ERSR"],"journal":["Frontiers in genetics"],"pagination":["1095428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871316"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptome-wide analysis reveals the molecular mechanisms of cannabinoid type II receptor agonists in cardiac injury induced by chronic psychological stress."],"pmcid":["PMC9871316"],"pubmed_authors":["Zhu Y","Zhang Y","Cao F","Wang Y","Qin C"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome-wide analysis reveals the molecular mechanisms of cannabinoid type II receptor agonists in cardiac injury induced by chronic psychological stress.","description":"<b>Background:</b> Growing evidence has supported that chronic psychological stress would cause heart damage, However the mechanisms involved are not clear and effective interventions are insufficient. Cannabinoid type 2 receptor (CB2R) can be a potential treatment for cardiac injury. This study is aimed to investigate the protective mechanism of CB2R agonist against chronic psychological stress-induced cardiac injury. <b>Methods:</b> A mouse chronic psychological stress model was constructed based on a chronic unpredictable stress pattern. Mice were performed a three-week psychological stress procedure, and cardiac tissues of them were collected for whole-transcriptome sequencing. Overlap analysis was performed on differentially expressed mRNAs (DE-mRNAs) and ER stress-related genes (ERSR","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T10:44:10.155Z","creation":"2025-04-04T11:51:32.25Z"},"accession":"S-EPMC9871316","cross_references":{"pubmed":["36704356"],"doi":["10.3389/fgene.2022.1095428"]}}