{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baleeiro FCF"],"funding":["Bundesministerium für Bildung und Forschung","Helmholtz-Gemeinschaft","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pagination":["322-336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(2)"],"pubmed_abstract":["Feeding microbial communities with both organic and inorganic substrates can improve sustainability and feasibility of chain elongation processes. Sustainably produced H<sub>2</sub> , CO<sub>2</sub> , and CO can be co-fed to microorganisms as a source for acetyl-CoA, while a small amount of an ATP-generating organic substrate helps overcome the kinetic hindrances associated with autotrophic carboxylate production. Here, we operated two semi-continuous bioreactor systems with continuous recirculation of H<sub>2</sub> , CO<sub>2</sub> , and CO while co-feeding an organic model feedstock (lactate and acetate) to understand how a mixotrophic community is shaped during carboxylate production. Contrary to the assumption that H<sub>2</sub> , CO<sub>2</sub> , and CO support chain elongation via et"],"journal":["Microbial biotechnology"],"pubmed_title":["Mixotrophic chain elongation with syngas and lactate as electron donors."],"pmcid":["PMC9871530"],"funding_grant_id":["88887.163504/2018‐00","01DQ17016","88887.163504/2018-00"],"pubmed_authors":["Kleinsteuber S","Strauber H","Neumann A","Baleeiro FCF","Raab J"],"additional_accession":[]},"is_claimable":false,"name":"Mixotrophic chain elongation with syngas and lactate as electron donors.","description":"Feeding microbial communities with both organic and inorganic substrates can improve sustainability and feasibility of chain elongation processes. Sustainably produced H<sub>2</sub> , CO<sub>2</sub> , and CO can be co-fed to microorganisms as a source for acetyl-CoA, while a small amount of an ATP-generating organic substrate helps overcome the kinetic hindrances associated with autotrophic carboxylate production. Here, we operated two semi-continuous bioreactor systems with continuous recirculation of H<sub>2</sub> , CO<sub>2</sub> , and CO while co-feeding an organic model feedstock (lactate and acetate) to understand how a mixotrophic community is shaped during carboxylate production. Contrary to the assumption that H<sub>2</sub> , CO<sub>2</sub> , and CO support chain elongation via et","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-10T06:54:31.908Z","creation":"2025-04-07T03:15:40.827Z"},"accession":"S-EPMC9871530","cross_references":{"pubmed":["36378491"],"doi":["10.1111/1751-7915.14163"]}}