biostudies-literatureUnknown13Wang QTTN is the most commonly mutated gene in skin cutaneous melanoma (SKCM). Tumor mutational burden (TMB) can generate new antigens that regulate the recognition of T cells, which will significantly affect the prognosis of patients. The TTN gene has a long coding sequence and a high number of mutant sites, which allows SKCM patients to produce higher TMB and may influence the immune response. It has been found that the overall survival (OS) of SKCM patients with TTN mutation was significantly higher than that of wild-type patients. However, the effect of TTN mutation on the immune microenvironment of SKCM has not been fully investigated. Here, we systematically explored the relationship and potential mechanisms between TTN mutation status and the immune response. We first revealed that TTN muFrontiers in genetics1084937https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871619biostudies-literatureIdentification and validation of a TTN-associated immune prognostic model for skin cutaneous melanoma.PMC9871619Zeng SWang QHuang XZhou RWang DfalseIdentification and validation of a TTN-associated immune prognostic model for skin cutaneous melanoma.TTN is the most commonly mutated gene in skin cutaneous melanoma (SKCM). Tumor mutational burden (TMB) can generate new antigens that regulate the recognition of T cells, which will significantly affect the prognosis of patients. The TTN gene has a long coding sequence and a high number of mutant sites, which allows SKCM patients to produce higher TMB and may influence the immune response. It has been found that the overall survival (OS) of SKCM patients with TTN mutation was significantly higher than that of wild-type patients. However, the effect of TTN mutation on the immune microenvironment of SKCM has not been fully investigated. Here, we systematically explored the relationship and potential mechanisms between TTN mutation status and the immune response. We first revealed that TTN mu2022-01-01T00:00:00Z20222025-08-31T03:09:01.233Z2025-04-05T21:40:56.669ZS-EPMC98716193670435310.3389/fgene.2022.1084937