biostudies-literatureUnknown14Perus LAgence Nationale de la Recherche<h4>Introduction</h4>The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC).<h4>Methods</h4>To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints.<h4>Results</h4>No global cFrontiers in aging neuroscience971220https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871772biostudies-literatureImpact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study.PMC9871772Dantoine TVellas BVillars HBurdet CBelleville SPerus LWillebois SRouaud OGervais CGonfrier SPayoux PDupuy CLapoujade BCotton FFaisant CDubois DBonafe ADartigues JFZanca MFontaine FTong MLYZueras ACostes CLivet PLehericy SDarcourt JFischer CCaillaud CDerumeaux HMalick-Loiseau CBernard-Bourzeix LChollet FBrigitte LFranon EPicat MAMisbah El Idrissi SManesco CVinel CLala FCognard CChanalet SRolland YMangin JFVan Kan GAHugon FBlatge CBordes SBegorre DBouhayia APader MLPays CClement JPGuyonnet SMarcet IDufouil CGourieux EDesclaux FCardinaud NBasset MFLouchart SGedeon CHitzel ACosta NBennys KLe Bars EVoisin TAndrieu SFaure VCombrouze EChupin MMolinier LColey NBonnefoy MOusset PJLaubarie-Mouret CPerret BDelrieu JCazaban-Campistron EMAPT/DSA groupQuipourt VRobert PSkolil PTouati LCantet CTerracol FDeverdun JGilbert BCarrie IRicolfi FWillis SRomano AGutierrez LAMarelli CCerda SLefebvre JFCarpuat CMonteil JMarilier SRoth SSudres KBonceour Martel MPMarie-Noelle-CuffiGasnier YFoubert AGabelle ATouchon JOlivier-Abbal PManckoundia PRebaudet PBadufle CPesce ABusto GCaspar-Bauguil SBonneville FDesormais IDelva FLebrun NPeiffer SMorin CBories LSaulnier IKhales KBarro-Belaygues NLe Duff FChaillou SSalles JPAllard MVan Dokkum LEHfalseImpact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study.<h4>Introduction</h4>The impact of multi-domain preventive interventions on older adults, in particular on those with higher risk to develop Alzheimer's disease (AD), could be beneficial, as it may delay cognitive decline. However, the precise mechanism of such positive impact is not fully understood and may involve brain reserve and adaptability of brain functional connectivity (FC).<h4>Methods</h4>To determine the effect of multidomain interventions (involving physical activity, cognitive training, nutritional counseling alone or in combination with omega-3 fatty acid supplementation and vs. a placebo) on the brain, longitudinal FC changes were assessed after 36 months of intervention on 100 older adults (above 70 year-old) with subjective cognitive complaints.<h4>Results</h4>No global c2022-01-01T00:00:00Z20222026-05-10T07:00:32.991Z2025-04-04T11:51:28.947ZS-EPMC98717723670562210.3389/fnagi.2022.971220