{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu IW"],"funding":["Ministry of Science and Technology","Chang Gung Memorial Hospital"],"pagination":["78-89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871851"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Chronic kidney disease (CKD) is pathologically correlated with a sophisticated milieu of innate and adaptive immune dysregulation, but the underlying immunological disturbances remain poorly understood.<h4>Methods</h4>To address this, we comprehensively interrogated cellular and soluble elements of the immune system by using high-dimensional flow cytometry to analyze peripheral blood mononuclear cells and performing cytokine/chemokine profiling of serum samples, respectively, in a cohort of 69 patients and 19 non-CKD controls.<h4>Results</h4>Altered serum levels of several cytokines/chemokines were identified, among which concentrations of stem cell factor (SCF) were found to be elevated with the progression of CKD and inversely correlated with estimated glomerular filtr"],"journal":["Clinical kidney journal"],"pubmed_title":["Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity."],"pmcid":["PMC9871851"],"funding_grant_id":["CMRPG2J024","BMRPE97","CORPG3K0251","MOST-109-2320-B-182A-017","CMRPG2M0201","CRRPG2H0124","MOST-110-2314-B-182A-053-MY3","MOST-110-2320-B-182A-012-MY3","CMRPG2C0342"],"pubmed_authors":["Twu YC","Chung WH","Chang YL","Hsieh WP","Chang LC","Hsu CK","Su SC","Wu YL","Yang CW","Yang HY","Wu IW"],"additional_accession":[]},"is_claimable":false,"name":"Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity.","description":"<h4>Background</h4>Chronic kidney disease (CKD) is pathologically correlated with a sophisticated milieu of innate and adaptive immune dysregulation, but the underlying immunological disturbances remain poorly understood.<h4>Methods</h4>To address this, we comprehensively interrogated cellular and soluble elements of the immune system by using high-dimensional flow cytometry to analyze peripheral blood mononuclear cells and performing cytokine/chemokine profiling of serum samples, respectively, in a cohort of 69 patients and 19 non-CKD controls.<h4>Results</h4>Altered serum levels of several cytokines/chemokines were identified, among which concentrations of stem cell factor (SCF) were found to be elevated with the progression of CKD and inversely correlated with estimated glomerular filtr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-07-09T13:24:19.271Z","creation":"2025-04-06T02:20:29.203Z"},"accession":"S-EPMC9871851","cross_references":{"pubmed":["36726440"],"doi":["10.1093/ckj/sfac196"]}}