{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Nguyen H"],"pubmed_abstract":["<h4>Introduction</h4>Previous studies verify the formation of enzymatically post-translationally modified (PTM) self-peptides and their preferred recognition by T cells in subjects with type 1 diabetes (T1D). However, questions remain about the relative prevalence of T cells that recognize PTM self-peptides derived from different antigens, their functional phenotypes, and whether their presence correlates with a specific disease endotype.<h4>Methods</h4>To address this question, we identified a cohort of subjects with T1D who had diverse levels of residual beta cell function. Using previously developed HLA class II tetramer reagents, we enumerated T cells that recognize PTM GAD epitopes in the context of DRB1*04:01 or PTM IA2 epitopes in the context of DQB1*03:02 (DQ8).<h4>Results</h4>Cons"],"journal":["Frontiers in immunology"],"pagination":["1015855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9871889"],"repository":["biostudies-literature"],"pubmed_title":["Characterizing T cell responses to enzymatically modified beta cell neo-epitopes."],"pmcid":["PMC9871889"],"pubmed_authors":["Arribas-Layton D","Chow IT","Nguyen H","Kwok WW","Speake C","Hessner MJ","Greenbaum CJ","James EA"],"additional_accession":[]},"is_claimable":false,"name":"Characterizing T cell responses to enzymatically modified beta cell neo-epitopes.","description":"<h4>Introduction</h4>Previous studies verify the formation of enzymatically post-translationally modified (PTM) self-peptides and their preferred recognition by T cells in subjects with type 1 diabetes (T1D). However, questions remain about the relative prevalence of T cells that recognize PTM self-peptides derived from different antigens, their functional phenotypes, and whether their presence correlates with a specific disease endotype.<h4>Methods</h4>To address this question, we identified a cohort of subjects with T1D who had diverse levels of residual beta cell function. Using previously developed HLA class II tetramer reagents, we enumerated T cells that recognize PTM GAD epitopes in the context of DRB1*04:01 or PTM IA2 epitopes in the context of DQB1*03:02 (DQ8).<h4>Results</h4>Cons","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T06:20:44.649Z","creation":"2025-04-05T21:40:19.857Z"},"accession":"S-EPMC9871889","cross_references":{"pubmed":["36703975"],"doi":["10.3389/fimmu.2022.1015855"]}}