{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Blanco CO"],"pubmed_abstract":["Water is ubiquitous in olefin metathesis, at levels ranging from contaminant to cosolvent. It is also non-benign. Water-promoted catalyst decomposition competes with metathesis, even for \"robust\" ruthenium catalysts. Metathesis is hence typically noncatalytic for demanding reactions in water-rich environments (e.g., chemical biology), a challenge as the Ru decomposition products promote unwanted reactions such as DNA degradation. To date, only the first step of the decomposition cascade is understood: catalyst aquation. Here we demonstrate that the aqua species dramatically accelerate both β-elimination of the metallacyclobutane intermediate and bimolecular decomposition of four-coordinate [RuCl(H<sub>2</sub>O)<sub>n</sub>(L)(=CHR)]Cl. Decomposition can be inhibited by blocking aquation and β-elimination."],"journal":["ACS catalysis"],"pagination":["1097-1102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872090"],"repository":["biostudies-literature"],"pubmed_title":["Water-Accelerated Decomposition of Olefin Metathesis Catalysts."],"pmcid":["PMC9872090"],"pubmed_authors":["Fogg DE","Blanco CO"],"additional_accession":[]},"is_claimable":false,"name":"Water-Accelerated Decomposition of Olefin Metathesis Catalysts.","description":"Water is ubiquitous in olefin metathesis, at levels ranging from contaminant to cosolvent. It is also non-benign. Water-promoted catalyst decomposition competes with metathesis, even for \"robust\" ruthenium catalysts. Metathesis is hence typically noncatalytic for demanding reactions in water-rich environments (e.g., chemical biology), a challenge as the Ru decomposition products promote unwanted reactions such as DNA degradation. To date, only the first step of the decomposition cascade is understood: catalyst aquation. Here we demonstrate that the aqua species dramatically accelerate both β-elimination of the metallacyclobutane intermediate and bimolecular decomposition of four-coordinate [RuCl(H<sub>2</sub>O)<sub>n</sub>(L)(=CHR)]Cl. Decomposition can be inhibited by blocking aquation and β-elimination.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T13:17:20.981Z","creation":"2025-04-06T14:12:56.023Z"},"accession":"S-EPMC9872090","cross_references":{"pubmed":["36714054"],"doi":["10.1021/acscatal.2c05573"]}}