biostudies-literatureUnknown52(1)Ali M<h4>Background</h4>There is a growing concern with inappropriate, excessive perioperative blood transfusions. Understanding the influence of low preoperative hemoglobin (Hgb) on perioperative blood transfusion (PBT) in head and neck cancer (HNC) surgery with free flap reconstruction may help guide clinical practice to reduce inappropriate treatment among these patients. The objective is to synthesize evidence regarding the association between preoperative Hgb and PBT among major HNC free flap surgeries.<h4>Methods</h4>Terms and synonyms for HNC surgical procedures, Hgb and PBT were used to search MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials and Cochrane Database of Reviews from inception to February 2020. Reference lists of included full texts and studies reportiJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale3https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872343biostudies-literaturePreoperative hemoglobin and perioperative blood transfusion in major head and neck surgery: a systematic review and meta-analysis.PMC9872343Sauro KMDort JCAli MfalsePreoperative hemoglobin and perioperative blood transfusion in major head and neck surgery: a systematic review and meta-analysis.<h4>Background</h4>There is a growing concern with inappropriate, excessive perioperative blood transfusions. Understanding the influence of low preoperative hemoglobin (Hgb) on perioperative blood transfusion (PBT) in head and neck cancer (HNC) surgery with free flap reconstruction may help guide clinical practice to reduce inappropriate treatment among these patients. The objective is to synthesize evidence regarding the association between preoperative Hgb and PBT among major HNC free flap surgeries.<h4>Methods</h4>Terms and synonyms for HNC surgical procedures, Hgb and PBT were used to search MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials and Cochrane Database of Reviews from inception to February 2020. Reference lists of included full texts and studies reporti2023-01-01T00:00:00Z2023 Jan2025-04-19T14:29:26.401Z2025-04-19T14:29:26.401ZS-EPMC98723433669107110.1186/s40463-022-00588-4