{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Cuenca I"],"funding":["Spanish Ministry of Economy","NEUROCENTRO","Ministerio de Ciencia e Innovación","Institute of Health of Carlos III of the Spanish Ministry of Science and Innovation","Spanish Ministry of Economy and Competitiveness","Universidad Complutense de Madrid"],"pagination":["19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Background
The earliest pathological features of Alzheimer's disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alterations in these ophthalmological measures, as well as in resting-state electrophysiological activity. However, it is unknown whether the ophthalmological alterations are related to the visual-related electrophysiological activity. Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease.Methods
In total, 144 healthy su"],"journal":["Alzheimer's research & therapy"],"pubmed_title":["Early visual alterations in individuals at-risk of Alzheimer's disease: a multidisciplinary approach."],"pmcid":["PMC9872347"],"funding_grant_id":["B2017/BMD-3760","RD16/0008/0005","RED2018-102499-T","CT42/18-CT43/18","PRE2019-087612","PSI2015-68793-C3-1-R [D601],","FPU18/05768"],"pubmed_authors":["Gil P","Barabash A","Nebreda A","de Frutos-Lucas J","Garcia-Colomo A","Salazar JJ","Bruna R","Ramirez-Torano F","Lopez-Cuenca I","Maestu F","Salobrar-Garcia E","Ramirez JM","de Hoz R","Ramirez AI"],"additional_accession":[]},"is_claimable":false,"name":"Early visual alterations in individuals at-risk of Alzheimer's disease: a multidisciplinary approach.","description":"Background
The earliest pathological features of Alzheimer's disease (AD) appear decades before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal structural changes and functional visual alterations. Healthy individuals at high risk of developing AD present alterations in these ophthalmological measures, as well as in resting-state electrophysiological activity. However, it is unknown whether the ophthalmological alterations are related to the visual-related electrophysiological activity. Elucidating this relationship is paramount to understand the mechanisms underlying the early deterioration of the system and an important step in assessing the suitability of these measures as early biomarkers of disease.Methods
In total, 144 healthy su","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-10T07:01:22.57Z","creation":"2024-12-04T13:08:20.89Z"},"accession":"S-EPMC9872347","cross_references":{"pubmed":["36694201"],"doi":["10.1186/s13195-023-01166-0"]}}