{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Fleischer JR"],"funding":["Herzzentrum Göttingen"],"pubmed_abstract":["<h4>Background</h4>Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies available. However, only a subgroup of metastases uses sprouting angiogenesis to secure their nutrients and oxygen supply, while others rely on vessel co-option (VCO). The distinct mode of vascularization is reflected by specific histopathological growth patterns (HGPs), which have proven prognostic and predictive significance. Nevertheless, their molecular mechanisms are poorly understood.<h4>Methods</h4>We evaluated CRCLM from 225 patients regarding their HGP and clinical data. Moreover, we performed spatial (21,804 spots) and single-cell (22,419 "],"journal":["Molecular cancer"],"pagination":["17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872436"],"repository":["biostudies-literature"],"pubmed_title":["Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution."],"pmcid":["PMC9872436"],"pubmed_authors":["Conradi LC","De Oliveira T","Kuffer S","Planque M","Fleischer JR","Fendt SM","Karras PJ","Beißbarth T","Vermeulen P","Teuwen LA","Kalucka J","Zeisberg EM","Bohnenberger H","Haas G","Bleckmann A","Schmitt AM","Xu X","Ghadimi M"],"additional_accession":[]},"is_claimable":false,"name":"Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution.","description":"<h4>Background</h4>Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies available. However, only a subgroup of metastases uses sprouting angiogenesis to secure their nutrients and oxygen supply, while others rely on vessel co-option (VCO). The distinct mode of vascularization is reflected by specific histopathological growth patterns (HGPs), which have proven prognostic and predictive significance. Nevertheless, their molecular mechanisms are poorly understood.<h4>Methods</h4>We evaluated CRCLM from 225 patients regarding their HGP and clinical data. Moreover, we performed spatial (21,804 spots) and single-cell (22,419 ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-25T22:34:53.094Z","creation":"2025-04-06T09:08:10.678Z"},"accession":"S-EPMC9872436","cross_references":{"pubmed":["36691028"],"doi":["10.1186/s12943-023-01713-1"]}}