{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sukenikova L"],"funding":["Agentura Pro Zdravotnický Výzkum České Republiky","lékařská fakulta Univerzity Karlovy"],"pagination":["1038328"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872645"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<h4>Introduction</h4>Probiotic administration seems to be a rational approach to promote maturation of the neonatal immune system. Mutual interaction of the microbiota with the host immune system is critical for the setting of appropriate immune responses including a tolerogenic one and thevmaintenance of homeostasis. On the other hand, our knowledge on the modes of actions of probiotics is still scarce.<h4>Methods</h4>In our study, probiotic strain Escherichia coli O83:K24:H31 (EcO83) was administered to neonates of allergic mothers (AMs; neonates with increased risk for allergy development) within 48 h after the delivery, and the impact of this early postnatal supplementation on allergy incidence and selected immune markers has been analyzed 10 years after the primary EcO83 administratio"],"journal":["Frontiers in immunology"],"pubmed_title":["Effect of early postnatal supplementation of newborns with probiotic strain <i>E. coli</i> O83:K24:H31 on allergy incidence, dendritic cells, and microbiota."],"pmcid":["PMC9872645"],"funding_grant_id":["AZV 15-26877A , NU20-05-00038"],"pubmed_authors":["Thon T","Petraskova P","Cerny V","Kocourkova I","Musil Z","Prokesova L","Novotna O","Kolarova L","Lodinova-Zadnikova R","Borakova K","Roubalova R","Sukenikova L","Jiraskova Zakostelska Z","Hrdy J","Valenta Z"],"additional_accession":[]},"is_claimable":false,"name":"Effect of early postnatal supplementation of newborns with probiotic strain <i>E. coli</i> O83:K24:H31 on allergy incidence, dendritic cells, and microbiota.","description":"<h4>Introduction</h4>Probiotic administration seems to be a rational approach to promote maturation of the neonatal immune system. Mutual interaction of the microbiota with the host immune system is critical for the setting of appropriate immune responses including a tolerogenic one and thevmaintenance of homeostasis. On the other hand, our knowledge on the modes of actions of probiotics is still scarce.<h4>Methods</h4>In our study, probiotic strain Escherichia coli O83:K24:H31 (EcO83) was administered to neonates of allergic mothers (AMs; neonates with increased risk for allergy development) within 48 h after the delivery, and the impact of this early postnatal supplementation on allergy incidence and selected immune markers has been analyzed 10 years after the primary EcO83 administratio","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T10:51:55.666Z","creation":"2024-11-19T19:27:59.164Z"},"accession":"S-EPMC9872645","cross_references":{"pubmed":["36703968"],"doi":["10.3389/fimmu.2022.1038328"]}}