biostudies-literatureSukenikova LAgentura Pro Zdravotnický Výzkum České Republikylékařská fakulta Univerzity Karlovy1038328https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872645biostudies-literatureUnknown13<h4>Introduction</h4>Probiotic administration seems to be a rational approach to promote maturation of the neonatal immune system. Mutual interaction of the microbiota with the host immune system is critical for the setting of appropriate immune responses including a tolerogenic one and thevmaintenance of homeostasis. On the other hand, our knowledge on the modes of actions of probiotics is still scarce.<h4>Methods</h4>In our study, probiotic strain Escherichia coli O83:K24:H31 (EcO83) was administered to neonates of allergic mothers (AMs; neonates with increased risk for allergy development) within 48 h after the delivery, and the impact of this early postnatal supplementation on allergy incidence and selected immune markers has been analyzed 10 years after the primary EcO83 administratioFrontiers in immunologyEffect of early postnatal supplementation of newborns with probiotic strain <i>E. coli</i> O83:K24:H31 on allergy incidence, dendritic cells, and microbiota.PMC9872645AZV 15-26877A , NU20-05-00038Thon TPetraskova PCerny VKocourkova IMusil ZProkesova LNovotna OKolarova LLodinova-Zadnikova RBorakova KRoubalova RSukenikova LJiraskova Zakostelska ZHrdy JValenta ZfalseEffect of early postnatal supplementation of newborns with probiotic strain <i>E. coli</i> O83:K24:H31 on allergy incidence, dendritic cells, and microbiota.<h4>Introduction</h4>Probiotic administration seems to be a rational approach to promote maturation of the neonatal immune system. Mutual interaction of the microbiota with the host immune system is critical for the setting of appropriate immune responses including a tolerogenic one and thevmaintenance of homeostasis. On the other hand, our knowledge on the modes of actions of probiotics is still scarce.<h4>Methods</h4>In our study, probiotic strain Escherichia coli O83:K24:H31 (EcO83) was administered to neonates of allergic mothers (AMs; neonates with increased risk for allergy development) within 48 h after the delivery, and the impact of this early postnatal supplementation on allergy incidence and selected immune markers has been analyzed 10 years after the primary EcO83 administratio2022-01-01T00:00:00Z20222026-05-27T10:51:55.666Z2024-11-19T19:27:59.164ZS-EPMC98726453670396810.3389/fimmu.2022.1038328