biostudies-literatureUnknown12Reiss ZMinisterstvo Zdravotnictví Ceské RepublikyMikrobiologický Ústav, Akademie Věd České RepublikyCrohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where the role of gut but not skin dysbiosis is well recognized. Inhibitors of TNF have been successful in IBD treatment, but up to a quarter of patients suffer from unpredictable skin adverse events (SkAE). For this purpose, we analyzed temporal dynamics of skin microbiota and serum markers of inflammation and epithelial barrier integrity during anti-TNF therapy and SkAE manifestation in IBD patients. We observed that the skin microbiota signature of IBD patients differs markedly from healthy subjects. In particular, the skin microbiota of CD patients differs significantly from that of UC patients and healthy subjects, mainly in the retroauricular crease. In addition, we showed that anti-TNFrontiers in cellular and infection microbiology1064537https://www.ebi.ac.uk/biostudies/studies/S-EPMC9872723biostudies-literatureSkin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy.PMC9872723Kreisinger JBajer LThon TReiss ZSchierova DKostovcikova KCoufal SMihula MKverka MLukas MNovakova MJackova ZRoubalova RGalanova NTlaskalova-Hogenova HKolar MVasatko MJiraskova Zakostelska ZRob FTresnak Hercogova JfalseSkin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy.Crohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where the role of gut but not skin dysbiosis is well recognized. Inhibitors of TNF have been successful in IBD treatment, but up to a quarter of patients suffer from unpredictable skin adverse events (SkAE). For this purpose, we analyzed temporal dynamics of skin microbiota and serum markers of inflammation and epithelial barrier integrity during anti-TNF therapy and SkAE manifestation in IBD patients. We observed that the skin microbiota signature of IBD patients differs markedly from healthy subjects. In particular, the skin microbiota of CD patients differs significantly from that of UC patients and healthy subjects, mainly in the retroauricular crease. In addition, we showed that anti-TN2022-01-01T00:00:00Z20222026-05-10T07:00:34.741Z2025-04-04T11:51:29.817ZS-EPMC98727233670410710.3389/fcimb.2022.1064537