{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang KM"],"funding":["SNUH Research Fund","Ministry of Science, ICT, and Future Planning, South Korea","Ministry of Health & Welfare, South Korea","National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT)","NIA NIH HHS","Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety)","National Institute of Aging, USA","Brain Research Program through the NRF of Korea funded by the Ministry of Science, ICT & Future Planning","Seoul National University Hospital"],"pagination":["577-586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9873511"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(2)"],"pubmed_abstract":["<h4>Aims</h4>The aim of this study was to investigate the associations of enlarged perivascular spaces (EPVS) in the basal ganglia (BG) and centrum semiovale (CSO) with beta-amyloid (Aβ) and tau deposition in older adults with a diverse cognitive spectrum.<h4>Methods</h4>A total of 163 (68 cognitively normal and 95 cognitively impaired) older participants underwent [<sup>11</sup> C] Pittsburgh compound B and [<sup>18</sup> F] AV-1451 PET, and MRI. EPVS in the BG and CSO and other small vessel disease markers, such as white matter hyperintensities, lacunes, and deep and lobar microbleeds, were assessed.<h4>Results</h4>Increased EPVS in the BG showed a significant association with lower cerebral tau deposition, even after controlling for other small vessel disease markers. Further exploratory analyses showed that this association was significant in cognitively impaired, Aβ-positive, or APOE4-positive individuals, but not significant in the cognitively normal, Aβ-negative, or APOE4-negative participants. In contrast to EPVS in the BG, EPVS in the CSO did not have any relationship with cerebral tau deposition. In addition, none of the two types of EPVS were associated with cerebral Aβ deposition.<h4>Conclusion</h4>Brain tau deposition appears to be reduced with increased EPVS in the BG, especially in individuals with cognitive impairment, pathological amyloid burden, or genetic Alzheimer's disease risk."],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Enlarged perivascular spaces are associated with decreased brain tau deposition."],"pmcid":["PMC9873511"],"funding_grant_id":["2021R1C1C1006407","U01 AG072177","2018M3C7A1056888","NRF-2014M3C7A1046042","U01AG072177","9991006735","HI18C0630 & HI19C0149","KMDF_PR_20200901_0062","0420210750","3020200030"],"pubmed_authors":["Lee YS","Jung G","Lee DY","Kang KM","KBASE Research Group","Ahn H","Lee JY","Byun MS","Kim YK","Sohn CH","Kim MJ","Yi D","Lee KH"],"additional_accession":[]},"is_claimable":false,"name":"Enlarged perivascular spaces are associated with decreased brain tau deposition.","description":"<h4>Aims</h4>The aim of this study was to investigate the associations of enlarged perivascular spaces (EPVS) in the basal ganglia (BG) and centrum semiovale (CSO) with beta-amyloid (Aβ) and tau deposition in older adults with a diverse cognitive spectrum.<h4>Methods</h4>A total of 163 (68 cognitively normal and 95 cognitively impaired) older participants underwent [<sup>11</sup> C] Pittsburgh compound B and [<sup>18</sup> F] AV-1451 PET, and MRI. EPVS in the BG and CSO and other small vessel disease markers, such as white matter hyperintensities, lacunes, and deep and lobar microbleeds, were assessed.<h4>Results</h4>Increased EPVS in the BG showed a significant association with lower cerebral tau deposition, even after controlling for other small vessel disease markers. Further exploratory analyses showed that this association was significant in cognitively impaired, Aβ-positive, or APOE4-positive individuals, but not significant in the cognitively normal, Aβ-negative, or APOE4-negative participants. In contrast to EPVS in the BG, EPVS in the CSO did not have any relationship with cerebral tau deposition. In addition, none of the two types of EPVS were associated with cerebral Aβ deposition.<h4>Conclusion</h4>Brain tau deposition appears to be reduced with increased EPVS in the BG, especially in individuals with cognitive impairment, pathological amyloid burden, or genetic Alzheimer's disease risk.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T20:35:14.636Z","creation":"2025-04-04T20:35:14.636Z"},"accession":"S-EPMC9873511","cross_references":{"pubmed":["36468423"],"doi":["10.1111/cns.14040"]}}