{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thompson RC"],"funding":["NCATS NIH HHS","Swiss National Science Foundation","NIDDK NIH HHS","NIAID NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","U.S. Department of Health & Human Services | NIH | National Cancer Institute","NCI NIH HHS","NIH HHS"],"pagination":["236-246"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9873574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected hospitalized individuals who were followed clinically into the post-acute period. Distinct gene expression signatures of post-acute sequelae were already present in whole blood during acute infection, with innate and adaptive immune cells implicated in different symptoms. Two clusters of sequelae exhibited divergent plasma-cell-associated gene expression patterns. In one cluster, sequelae associated with higher expression of immunoglobulin-related genes in an anti-spike antibody titer-dependent manner. In the other, sequelae associated independently"],"journal":["Nature medicine"],"pubmed_title":["Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae."],"pmcid":["PMC9873574"],"funding_grant_id":["U24 CA224319","S10 OD030463","S10 OD026880","UL1 TR004419","CA224319","310030","P30 CA196521","R01 AI141953","NRP 78","198431","3R01AI141953-02S1","310030-200669","CA196521","3R01AI141953-02S2","U01 DK124165","DK124165","4078P0-198431"],"pubmed_authors":["Agashe C","Serrano S","Mount Sinai COVID-19 Biobank Team","Vaninov N","Xue L","Patel M","Marvin R","Walker L","Wang YC","Kim-Schulze S","Argueta K","Patel V","Silva P","Yuan D","Bailey R","Young S","Rodrigues A","Stefanos H","Le Berichel J","Cosgrove D","Liharska LE","Feng S","Van Der Heide V","Hochman A","Zaks N","Jaladanki S","Reyes-Torres I","Tuballes K","Merad M","Sebra R","Heath JR","Boyman O","Beckmann AG","Moya E","Mouskas K","Kelly G","Johnson JS","Cossarini F","Glicksberg BS","Merzier E","Tyler SR","Chung J","Gyimesi G","Leventhal MB","Yu A","Geanon D","Redes J","Del Valle DM","Eber N","Machado R","Dayal B","Thompson RC","Nadkarni G","Akyatan A","Ascolillo S","Onel K","Cedillo MA","Wilson KM","Horta L","Meyer D","Wacker D","Chien J","Chen ST","Ellis E","Fernandes M","Gnjatic S","Dawson T","Dul K","Fishman N","Maskey S","Tin M","Dave A","Humblin E","Gelb BD","Comella PH","Cimen Bozkus C","Jamal H","Jordan D","Soares Schanoski A","Zaki N","Scott I","Morris S","Sloofman L","Gonzalez-Kozlova E","Mollaoglu G","Alvarez K","Vlachos K","Nisenholtz M","Buckup M","Lee GH","Sweeney R","Harris J","Cambron L","Argmann C","Sridhar SH","Lacunza J","Bose S","Shervey M","Alibo E","Yishak M","Roudko V","Wilson J","Shah H","Hatem S","Martin G","Walsh H","Lebovitch D","Hartnett M","Begani P","Wilkins L","Hoffman GE","Mahmood Z","Matthews P","Brown SA","Carrara G","Barcessat V","Charney AW","Fabris F","Upadhyaya B","Alesso-Carra K","Gangadharan S","Lindblad K","Amabile A","Lee J","Elaiho C","Kim J","Leech J","Lee G","Lee B","Pruitt C","Simons NW","Ounadjela M","Dhainaut M","Chang C","Hamdani M","Zha R","Cheng E","Karim S","Mehandru S","Bravo P","Chang S","Schadt EE","Herbinet M","Yi N","Ruiz E","Wilk CM","Lansky A","Cervia C","Agrawal P","Straw M","Hook J","Mar K","Ofori-Amanfo G","Wang B","Handler D","Teague C","Vaid A","Kang G","Calorossi S","Herrera E","Soto J","Xie H","Lepow L","Wang W","Burka L","Meckel K","Rahman A","Roussos P","Rathi S","Huckins L","Marron TU","Eaton M","Grabowska J","Carbonell G","Tabachnikova A","Beckmann ND","Yeboah NA","Chowdhury M","Karekar N","Rodriguez A","Francoeur NJ","Madrid K","Bogunovic D","Dornfeld R","Falci D","Cotter L","Nie K","Batchelor C","Fennessy B","Smith M","Faith J","Mercedes C","Scalzo P","Kumar A","Livanos A"],"additional_accession":[]},"is_claimable":false,"name":"Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae.","description":"Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected hospitalized individuals who were followed clinically into the post-acute period. Distinct gene expression signatures of post-acute sequelae were already present in whole blood during acute infection, with innate and adaptive immune cells implicated in different symptoms. Two clusters of sequelae exhibited divergent plasma-cell-associated gene expression patterns. In one cluster, sequelae associated with higher expression of immunoglobulin-related genes in an anti-spike antibody titer-dependent manner. In the other, sequelae associated independently","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-07-14T19:09:41.473Z","creation":"2025-04-04T13:37:07.465Z"},"accession":"S-EPMC9873574","cross_references":{"pubmed":["36482101"],"doi":["10.1038/s41591-022-02107-4"]}}