biostudies-literatureChadchan SBNICHD NIH HHSNCI NIH HHSU.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development28https://www.ebi.ac.uk/biostudies/studies/S-EPMC9873805biostudies-literatureUnknown9(1)Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct impact of microbiota and microbiota-derived metabolites on the endometriosis disease progression is largely unknown. To understanCell death discoveryGut microbiota and microbiota-derived metabolites promotes endometriosis.PMC9873805R01HD065435R00HD080742R01 CA220297R01 CA216426R00 HD080742R01 HD065435P30 CA125123R01 HD102680R01HD102680Kommagani RPutluri SAmbati CRKau ALStallings CLNaik SKPopli PLint MATalwar CChadchan SBfalseGut microbiota and microbiota-derived metabolites promotes endometriosis.Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct impact of microbiota and microbiota-derived metabolites on the endometriosis disease progression is largely unknown. To understan2023-01-01T00:00:00Z2023 Jan2025-04-04T13:07:40.194Z2025-04-04T13:07:40.194ZS-EPMC98738053669385310.1038/s41420-023-01309-0