biostudies-literatureUnknown12Tian G<h4>Background</h4>Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifificantly increased. Pyroptosis is a new form of programmed lytic death that has been recently discovered. Caspase 4 (CASP4) plays a key role in pyroptosis. Many studies have shown that pyroptosis is not only related to inflflammation but is also closely related to the occurrence and development of most tumors. This study aimed to prove that CASP4 has a key role in the mechanism of gliomas.<h4>Methods</h4>We used expression data from The Cancer Genome Atlas and the Chinese Glioma Genome AtFrontiers in oncology1025065https://www.ebi.ac.uk/biostudies/studies/S-EPMC9874090biostudies-literatureCASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas.PMC9874090Fang XBai SKang WPan YTian GLi QNiu LLuo YWang HYuan GfalseCASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas.<h4>Background</h4>Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemotherapy. However, the long-term survival rate has not signifificantly increased. Pyroptosis is a new form of programmed lytic death that has been recently discovered. Caspase 4 (CASP4) plays a key role in pyroptosis. Many studies have shown that pyroptosis is not only related to inflflammation but is also closely related to the occurrence and development of most tumors. This study aimed to prove that CASP4 has a key role in the mechanism of gliomas.<h4>Methods</h4>We used expression data from The Cancer Genome Atlas and the Chinese Glioma Genome At2022-01-01T00:00:00Z20222025-04-26T13:25:51.016Z2025-04-06T14:11:22.391ZS-EPMC98740903671356010.3389/fonc.2022.1025065