biostudies-literatureUnknown13Nan SFundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of China<h4>Introduction</h4>The primo vascular system (PVS), an intensive network structure, has been claimed to be representative of the acupuncture meridian. Here, we explored the role of the PVS in local enteritis and its modification by acupuncture.<h4>Methods</h4>Chronic cecitis in rabbits was induced by 2,4,6-trinitro-benzene-sulfonic acid (TNBS). The PVS on the cecum was visualized with trypan blue staining, and collected with the help of microsurgical forceps under an optical stereomicroscope.<h4>Results</h4>The increased primo vessels (PVs) and primo nodes (PNs) of the PVS on the surface of the cecum were induced by local inflammation, which was positively correlated with the inflammatory cells in the cecal mucosa. Tandem mass tag (TMT) based proteomic analysis revealed that 110 differenFrontiers in immunology1072996https://www.ebi.ac.uk/biostudies/studies/S-EPMC9874324biostudies-literatureThe involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.PMC9874324Ding YZhu JNan SMa NYin RWan JWang XLei QDing MfalseThe involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.<h4>Introduction</h4>The primo vascular system (PVS), an intensive network structure, has been claimed to be representative of the acupuncture meridian. Here, we explored the role of the PVS in local enteritis and its modification by acupuncture.<h4>Methods</h4>Chronic cecitis in rabbits was induced by 2,4,6-trinitro-benzene-sulfonic acid (TNBS). The PVS on the cecum was visualized with trypan blue staining, and collected with the help of microsurgical forceps under an optical stereomicroscope.<h4>Results</h4>The increased primo vessels (PVs) and primo nodes (PNs) of the PVS on the surface of the cecum were induced by local inflammation, which was positively correlated with the inflammatory cells in the cecal mucosa. Tandem mass tag (TMT) based proteomic analysis revealed that 110 differen2022-01-01T00:00:00Z20222026-07-15T22:32:20.631Z2025-04-06T14:12:08.153ZS-EPMC98743243671338810.3389/fimmu.2022.1072996