{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rouers A"],"funding":["FDA HHS","Agency for Science, Technology and Research","U.S. Food and Drug Administration"],"pagination":["e28258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9874655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(1)"],"pubmed_abstract":["Waning antibody levels against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of variants of concern highlight the need for booster vaccinations. This is particularly important for the elderly population, who are at a higher risk of developing severe coronavirus disease 2019 (COVID-19) disease. While studies have shown increased antibody responses following booster vaccination, understanding the changes in T and B cell compartments induced by a third vaccine dose remains limited. We analyzed the humoral and cellular responses in subjects who received either a homologous messenger RNA(mRNA) booster vaccine (BNT162b2 + BNT162b2 + BNT162b2; ''BBB\") or a heterologous mRNA booster vaccine (BNT162b2 + BNT162b2 + mRNA-1273; ''BBM\") at Day 0 (prebooster), Day 7, and"],"journal":["Journal of medical virology"],"pubmed_title":["Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters."],"pmcid":["PMC9874655"],"funding_grant_id":["75F40120C00085"],"pubmed_authors":["Lye DC","Chia PY","Wong JXE","Wang CI","Rao S","COVID-19 Study Group","Salleh SNM","Lin RJH","Lee TH","Bei W","Ren EC","Rouers A","Neo V","Poh XY","Wong N","Ng LFP","Yeo NK","Ong SWX","Tay MZ","Ngoh EZX","Teo J","Renia L","Young BE","Macary PA","Loh CY","Goh YS","Hor PX","Tan YJ","Qian X","Chang ZW","Lim C","Huang Y","Kam IKJ","Torres-Ruesta A","Fong SW"],"additional_accession":[]},"is_claimable":false,"name":"Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters.","description":"Waning antibody levels against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of variants of concern highlight the need for booster vaccinations. This is particularly important for the elderly population, who are at a higher risk of developing severe coronavirus disease 2019 (COVID-19) disease. While studies have shown increased antibody responses following booster vaccination, understanding the changes in T and B cell compartments induced by a third vaccine dose remains limited. We analyzed the humoral and cellular responses in subjects who received either a homologous messenger RNA(mRNA) booster vaccine (BNT162b2 + BNT162b2 + BNT162b2; ''BBB\") or a heterologous mRNA booster vaccine (BNT162b2 + BNT162b2 + mRNA-1273; ''BBM\") at Day 0 (prebooster), Day 7, and","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-29T05:32:47.323Z","creation":"2025-04-05T20:21:06.031Z"},"accession":"S-EPMC9874655","cross_references":{"pubmed":["36305052"],"doi":["10.1002/jmv.28258"]}}