biostudies-literatureSaifuddin ANational Institute for Health Research (NIHR)1460-1474https://www.ebi.ac.uk/biostudies/studies/S-EPMC9874879biostudies-literatureUnknown56(10)<h4>Background</h4>The COVID-19 pandemic offered a unique opportunity to understand inflammatory bowel disease (IBD) management during unexpected disruption. This could help to guide practice overall.<h4>Aims</h4>To compare prescribing behaviour for IBD flares and outcomes during the early pandemic with pre-pandemic findings METHODS: We performed an observational cohort study comprising patients who contacted IBD teams for symptomatic flares between March and June 2020 in 60 National Health Service trusts in the United Kingdom. Data were compared with a pre-pandemic cohort after propensity-matching for age and physician global assessment of disease activity.<h4>Results</h4>We included 1864 patients in each of the pandemic and pre-pandemic cohorts. The principal findings were reduced systemAlimentary pharmacology & therapeuticsTreatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID-19 pandemic: the PREPARE-IBD multicentre cohort study.PMC9874879CL-2022-06-003ACF-2020-24-001Williams MArasaradnam RPerkins RFlanagan PMulligan RVakeeswarasarma VHooper PButterworth JReddington ASikafi RCarr RTaylor JWoods ACotton SHart ANaylor DMahgoub SDavwar PPohl KSerna SPatel KTabuso MQuraishi MNHtun AMKemp KMorrison GBorg-Bartolo SLakeland MSeenan JPCurran CPeddada KShenoy ARamadan HDooks EArebi NShale MTurner KAlkhouri JMcCulloch ALamb CAJayasooriya NSherifat YHoward WBlackmore LClough JJagdish RSegal JPHicks LLimdi JAshraf MAbbesi AGhosh NBishop SBradley NIrving PBancil AGwiggner MGueroult AKorani MChaudhary RTunney RD'Souza AMir NRamadas ASaunders JFraser AOlabintan OCarter JKokwaro FVerma AAbusrewil AMurray CAbdale SMehta SBotwright EMurray JWalton HDawa KKHarlow CSabine JChurchhouse ARosiou KKennedy NBalarajah SBond ALobo AMehta SJFelwick RTownsend TWarner EGood LAghimien PMyers SQuarashi MLamb CBoyle SMcCaughan HCooney RTownsend GAyubi HChandy RLim SJohnson MWallace HFofaria RTham TSan EOMSasegbon AKhasawneh MDarie AMDyall LLisle JMorris LBayati MKhalil HQayyum FPeerally MTaucius DTroth TZafar MLindsay JBell APhillips FAl-Rifaie ABaillie SNaranjo ARimmer PGonzalez HARadford SRowland SChee DMazhar ZAhmed SHawthorne BLees CRitchie SGordon JThakor ASebastian SOwen HNaeck-Boolauky PLim YHAvades TMasri AMoran GDiong KLBritton DMahalingam AMalakar RKaragkouni FBrookes MJDisney BElias MFox RJohnston ESelinger CCook JBouri SGilroy LNavaratnam JSpeight ACole ALevison SDhar AMason JPREPARE-IBD CollaboratorsLucacui LDowney LRiley TBrailsford FFinegan MHutton TSarwar SKennedy NAYounge LCritchlow TMoffatt VRahmany SCuison FSteed HKent APowell NLevell ESebepos-Rogers GMendall MMarley FWidlak MSingh ALuber RMeah NGulliver JCartlidge PAllen PStansfield CSaifuddin ADart RRiggott CWang BFrunza CArms-Williams BPee LWen SBhat SLaverick SGrasso NBrown CKirkham FSivaji GWatson CKent AJMacDonald JButcher RSingh SHanna MHussain NSegal JSingh USubramanian SGhodeif ARadcliffe EShenderey RSethi SAppleby RBerry AMebarek LBrooks MConley TPatel KVPalmer-Jones CKoumoutsos IDin SKirkham BChatten KBrennan ESpence AJaved ASiakavellas SLyne HBhala NHicks LCKhan ZMcIlwaine SHarrison WPollok RChessbrough JMcCort TKuzhiyanjal AJKBhattacharyya JSheth RFong SConley TEAli AGuthrie SWalker GWalker GJNixon ENixon KBasit ACampbell RAndrea ANolan JKing AUmar NCampbell ISmith PJones GRKanagasundaram CKhan NKumar ASuseehran KfalseTreatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID-19 pandemic: the PREPARE-IBD multicentre cohort study.<h4>Background</h4>The COVID-19 pandemic offered a unique opportunity to understand inflammatory bowel disease (IBD) management during unexpected disruption. This could help to guide practice overall.<h4>Aims</h4>To compare prescribing behaviour for IBD flares and outcomes during the early pandemic with pre-pandemic findings METHODS: We performed an observational cohort study comprising patients who contacted IBD teams for symptomatic flares between March and June 2020 in 60 National Health Service trusts in the United Kingdom. Data were compared with a pre-pandemic cohort after propensity-matching for age and physician global assessment of disease activity.<h4>Results</h4>We included 1864 patients in each of the pandemic and pre-pandemic cohorts. The principal findings were reduced system2022-01-01T00:00:00Z2022 Nov2026-05-28T20:42:49.633Z2024-11-20T11:05:08.855ZS-EPMC98748793619656910.1111/apt.17223