{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gagliano L"],"funding":["Natural Sciences and Engineering Research Council of Canada","Canada Excellence Research Chairs, Government of Canada","Institut de Valorisation des Données","Fonds de Recherche du Québec - Nature et Technologies","Canadian Institutes of Health Research"],"pagination":["1089094"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9875007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<h4>Introduction</h4>While it is known that poor sleep is a seizure precipitant, this association remains poorly quantified. This study investigated whether seizures are preceded by significant changes in sleep efficiency as measured by a wearable equipped with an electrocardiogram, respiratory bands, and an accelerometer.<h4>Methods</h4>Nocturnal recordings from 47 people with epilepsy hospitalized at our epilepsy monitoring unit were analyzed (304 nights). Sleep metrics during nights followed by epileptic seizures (24 h post-awakening) were compared to those of nights which were not.<h4>Results</h4>Lower sleep efficiency (percentage of sleep during the night) was found in the nights preceding seizure days (<i>p</i> < 0.05). Each standard deviation decrease in sleep efficiency and increase in wake after sleep onset was respectively associated with a 1.25-fold (95 % CI: 1.05 to 1.42, <i>p</i> < 0.05) and 1.49-fold (95 % CI: 1.17 to 1.92, <i>p</i> < 0.01) increased odds of seizure occurrence the following day. Furthermore, nocturnal seizures were associated with significantly lower sleep efficiency and higher wake after sleep onset (<i>p</i> < 0.05), as well as increased odds of seizure occurrence following wake (OR: 5.86, 95 % CI: 2.99 to 11.77, <i>p</i> < 0.001).<h4>Discussion</h4>Findings indicate lower sleep efficiency during nights preceding seizures, suggesting that wearable sensors could be promising tools for sleep-based seizure-day forecasting in people with epilepsy."],"journal":["Frontiers in neurology"],"pubmed_title":["Decrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures."],"pmcid":["PMC9875007"],"funding_grant_id":["51628"],"pubmed_authors":["Toffa DH","Bou Assi E","Ding TY","Sawan M","Lesage F","Gagliano L","Nguyen DK","Robert M","Beauregard L"],"additional_accession":[]},"is_claimable":false,"name":"Decrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures.","description":"<h4>Introduction</h4>While it is known that poor sleep is a seizure precipitant, this association remains poorly quantified. This study investigated whether seizures are preceded by significant changes in sleep efficiency as measured by a wearable equipped with an electrocardiogram, respiratory bands, and an accelerometer.<h4>Methods</h4>Nocturnal recordings from 47 people with epilepsy hospitalized at our epilepsy monitoring unit were analyzed (304 nights). Sleep metrics during nights followed by epileptic seizures (24 h post-awakening) were compared to those of nights which were not.<h4>Results</h4>Lower sleep efficiency (percentage of sleep during the night) was found in the nights preceding seizure days (<i>p</i> < 0.05). Each standard deviation decrease in sleep efficiency and increase in wake after sleep onset was respectively associated with a 1.25-fold (95 % CI: 1.05 to 1.42, <i>p</i> < 0.05) and 1.49-fold (95 % CI: 1.17 to 1.92, <i>p</i> < 0.01) increased odds of seizure occurrence the following day. Furthermore, nocturnal seizures were associated with significantly lower sleep efficiency and higher wake after sleep onset (<i>p</i> < 0.05), as well as increased odds of seizure occurrence following wake (OR: 5.86, 95 % CI: 2.99 to 11.77, <i>p</i> < 0.001).<h4>Discussion</h4>Findings indicate lower sleep efficiency during nights preceding seizures, suggesting that wearable sensors could be promising tools for sleep-based seizure-day forecasting in people with epilepsy.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-09T10:26:31.434Z","creation":"2025-04-06T14:11:05.186Z"},"accession":"S-EPMC9875007","cross_references":{"pubmed":["36712456"],"doi":["10.3389/fneur.2022.1089094"]}}