biostudies-literatureGagliano LNatural Sciences and Engineering Research Council of CanadaCanada Excellence Research Chairs, Government of CanadaInstitut de Valorisation des DonnéesFonds de Recherche du Québec - Nature et TechnologiesCanadian Institutes of Health Research1089094https://www.ebi.ac.uk/biostudies/studies/S-EPMC9875007biostudies-literatureUnknown13<h4>Introduction</h4>While it is known that poor sleep is a seizure precipitant, this association remains poorly quantified. This study investigated whether seizures are preceded by significant changes in sleep efficiency as measured by a wearable equipped with an electrocardiogram, respiratory bands, and an accelerometer.<h4>Methods</h4>Nocturnal recordings from 47 people with epilepsy hospitalized at our epilepsy monitoring unit were analyzed (304 nights). Sleep metrics during nights followed by epileptic seizures (24 h post-awakening) were compared to those of nights which were not.<h4>Results</h4>Lower sleep efficiency (percentage of sleep during the night) was found in the nights preceding seizure days (<i>p</i> < 0.05). Each standard deviation decrease in sleep efficiency and increase in wake after sleep onset was respectively associated with a 1.25-fold (95 % CI: 1.05 to 1.42, <i>p</i> < 0.05) and 1.49-fold (95 % CI: 1.17 to 1.92, <i>p</i> < 0.01) increased odds of seizure occurrence the following day. Furthermore, nocturnal seizures were associated with significantly lower sleep efficiency and higher wake after sleep onset (<i>p</i> < 0.05), as well as increased odds of seizure occurrence following wake (OR: 5.86, 95 % CI: 2.99 to 11.77, <i>p</i> < 0.001).<h4>Discussion</h4>Findings indicate lower sleep efficiency during nights preceding seizures, suggesting that wearable sensors could be promising tools for sleep-based seizure-day forecasting in people with epilepsy.Frontiers in neurologyDecrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures.PMC987500751628Toffa DHBou Assi EDing TYSawan MLesage FGagliano LNguyen DKRobert MBeauregard LfalseDecrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures.<h4>Introduction</h4>While it is known that poor sleep is a seizure precipitant, this association remains poorly quantified. This study investigated whether seizures are preceded by significant changes in sleep efficiency as measured by a wearable equipped with an electrocardiogram, respiratory bands, and an accelerometer.<h4>Methods</h4>Nocturnal recordings from 47 people with epilepsy hospitalized at our epilepsy monitoring unit were analyzed (304 nights). Sleep metrics during nights followed by epileptic seizures (24 h post-awakening) were compared to those of nights which were not.<h4>Results</h4>Lower sleep efficiency (percentage of sleep during the night) was found in the nights preceding seizure days (<i>p</i> < 0.05). Each standard deviation decrease in sleep efficiency and increase in wake after sleep onset was respectively associated with a 1.25-fold (95 % CI: 1.05 to 1.42, <i>p</i> < 0.05) and 1.49-fold (95 % CI: 1.17 to 1.92, <i>p</i> < 0.01) increased odds of seizure occurrence the following day. Furthermore, nocturnal seizures were associated with significantly lower sleep efficiency and higher wake after sleep onset (<i>p</i> < 0.05), as well as increased odds of seizure occurrence following wake (OR: 5.86, 95 % CI: 2.99 to 11.77, <i>p</i> < 0.001).<h4>Discussion</h4>Findings indicate lower sleep efficiency during nights preceding seizures, suggesting that wearable sensors could be promising tools for sleep-based seizure-day forecasting in people with epilepsy.2022-01-01T00:00:00Z20222026-07-09T10:26:31.434Z2025-04-06T14:11:05.186ZS-EPMC98750073671245610.3389/fneur.2022.1089094