{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu LY"],"funding":["AHA Grant-in-Aid","NIAID NIH HHS","NHLBI NIH HHS","NIH"],"pagination":["805-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9875669"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(7)"],"pubmed_abstract":["<h4>Background</h4>Priming with cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances eosinophil migration and exacerbates the excessive accumulation of eosinophils within the bronchial mucosa of asthmatics. However, mechanisms that drive GM-CSF priming are incompletely understood. Notch signaling is an evolutionarily conserved pathway that regulates cellular processes, including migration, by integrating exogenous and cell-intrinsic cues. This study investigates the hypothesis that the priming-induced enhanced migration of human eosinophils requires the Notch signaling pathway.<h4>Methods</h4>Using pan Notch inhibitors and newly developed human antibodies that specifically neutralize Notch receptor 1 activation, we investigated a role for Notch signaling in "],"journal":["Allergy"],"pubmed_title":["Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils."],"pmcid":["PMC9875669"],"funding_grant_id":["R01 HL095699","R37 AI020241"],"pubmed_authors":["Xenakis JJ","Liu LY","Wang H","Spencer LA"],"additional_accession":[]},"is_claimable":false,"name":"Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils.","description":"<h4>Background</h4>Priming with cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances eosinophil migration and exacerbates the excessive accumulation of eosinophils within the bronchial mucosa of asthmatics. However, mechanisms that drive GM-CSF priming are incompletely understood. Notch signaling is an evolutionarily conserved pathway that regulates cellular processes, including migration, by integrating exogenous and cell-intrinsic cues. This study investigates the hypothesis that the priming-induced enhanced migration of human eosinophils requires the Notch signaling pathway.<h4>Methods</h4>Using pan Notch inhibitors and newly developed human antibodies that specifically neutralize Notch receptor 1 activation, we investigated a role for Notch signaling in ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2025-04-04T00:02:57.226Z","creation":"2025-04-04T00:02:57.226Z"},"accession":"S-EPMC9875669","cross_references":{"pubmed":["25846339"],"doi":["10.1111/all.12624"]}}