{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dixon-Suen SC"],"funding":["Consiglio Nazionale delle Ricerche","Cancer Council Victoria","Xerencia de Xestion Integrada de Vigo - SERGAS","Swedish Local hospital funds","Agence Nationale de la Recherche","NIEHS NIH HHS","David F. and Margaret T. Grohne Family Foundation","Sigrid Juselius Foundation","Gustav V Jubilee foundation","Macedonian Academy of Sciences and Arts","Helsinki University Hospital Research Fund","National Institutes of Health","National Health Service","German Breast Group GmbH","Gunnar Nilssons Cancerstiftelse","Against Breast Cancer","Research and Innovation Programme","National Institute for Health Research (NIHR)","Dutch Ministry of Public Health, Welfare and Sports","California Teachers Study Steering Committee","Canadian Cancer Society Research Institute","Vetenskapsrådet","Breast Cancer Now","Friends of Hannover Medical School","Victorian Health Promotion Foundation","Itä-Suomen Yliopisto","Oak Foundation","Cancerfonden","Breast Cancer Research Foundation","Baden Württemberg Ministry of Science, Research and Arts","Dietmar-Hopp Foundation","University Hospital of Erlangen","Stavros Niarchos Foundation","Victorian Cancer Agency","University of Utah","Acción Estratégica de Salud del Instituto de Salud Carlos III","Genome Québec","Wellcome Trust","Genome Canada","National Cancer Research Network","KWF Kankerbestrijding","European Regional Development Fund","Robert and Kate Niehaus Clinical Cancer Genetics Initiative","Rudolf Bartling Foundation","Kuopion Yliopistollinen Sairaala","National Cancer Institute’s Surveillance, Epidemiology and End Results Program","Komen Foundation for the Cure","Fru Berta Kamprads Stiftelse","K.G. Jebsen Centre for Breast Cancer Research","Institut Gustave Roussy","European Commission","Institute of Cancer Research","Ministry of Science and Higher Education, Poland","North Carolina University Cancer Research Fund","Herlev and Gentofte Hospital","Cancer Foundation Finland","Hamburger Krebsgesellschaft","Finnish Cancer Organizations","National Institute of Environmental Health Sciences","Chief Physician Johan Boserup and Lise Boserup Fund","Ministerio de Economia y Competitividad, Xunta de Galicia","Institut National de la Santé et de la Recherche Médicale","Instituto de Investigacion Biomedica Galicia Sur","National Breast Cancer Foundation","National Institute for Health Research University College London Hospitals Biomedical Research Centre","Freistaat Sachsen","Norges Forskningsråd","U.S. Department of Defense","Karolinska Institutet","Health Research Fund","Netherlands Cancer Registry","NIHR Manchester Biomedical Research Centre","Lon V Smith Foundation","NIHR Bristol Biomedical Research Centre","Hellenic Health Foundation","Centre International de Recherche sur le Cancer","New South Wales Cancer Council","Sundhed og Sygdom, Det Frie Forskningsråd","Associazione Italiana per la Ricerca sul Cancro","California Department of Public Health","Sheffield Experimental Cancer Medicine Centre","Institute of the Ruhr University Bochum","Centers for Disease Control and Prevention&apos;s National Program of Cancer Registries","American Cancer Society","VicHealth","Ministerio de Sanidad, Servicios Sociales e Igualdad","Robert Bosch Stiftung","Helmholtz Society","Cancer Fund of North Savo","Ligue Contre le Cancer","Intramural NIH HHS","Institut National Du Cancer","Victorian Breast Cancer Research Consortium","University of Crete","Huntsman Cancer Foundation","Dutch Prevention Funds","NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","Claudia von Schilling Foundation for Breast Cancer Research","Grant for SZBCS study","Medical Research Council","European Union&apos;s Horizon 2020 Research and Innovation Programme","Fonds Wetenschappelijk Onderzoek","National Health and Medical Research Council","Russian Foundation for Basic Research","LK Research Funds","Stockholms Läns Landsting","Bundesministerium für Bildung und Forschung","Mutuelle Générale de l’Education Nationale","Cancer Research UK","Fondation du cancer du sein du Québec","NCCDPHP CDC HHS","Kreftforeningen","Agence Nationale de Sécurité Sanitaire de l&apos;Alimentation, de l&apos;Environnement et du Travail","Huntsman Cancer Institute","Biobanking and Biomolecular Resources Research Infrastructure","Ministry of Science and Higher Education of the Russian Federation","Ovarian Cancer Research Fund","Consellería de Industria de la Xunta de Galicia","Canadian Institutes of Health Research","South Eastern Norway Health Authority","Deutsches Krebsforschungszentrum","Zorg Onderzoek Nederland","European Research Council","Utah Population Database","Institute for Prevention and Occupational Medicine of the German Social Accident Insurance","National Cancer Institute","Cancer Institute NSW","Lower Saxonian Cancer Society","Cancer Council Western Australia","Stichting Tegen Kanker","University of Bristol","Swedish Cancer Foundation","Deutsche Krebshilfe","Johanniter GmbH Bonn, Johanniter Krankenhaus","Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra","Bert von Kantzows foundation","World Cancer Research Fund","Ministère de l’Économie, Science et Innovation du Québec","Statistics Netherlands","NCI NIH HHS","Seventh Framework Programme","Fondation de France","Utah Cancer Registry","Märit and Hans Rausings Initiative Against Breast Cancer"],"pagination":["1157-1170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9876601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(20)"],"pubmed_abstract":["<h4>Objectives</h4>Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.<h4>Methods</h4>We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n<sub>snps</sub>=5) or sedentary time (n<sub>snps</sub>=6), or accelerometer-measured (n<sub>snps</sub>=1) or self-reported (n<sub>snps</sub>=5) vigorous physical activity.<h4>Results</h4>Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).<h4>Conclusion</h4>Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women."],"journal":["British journal of sports medicine"],"pubmed_title":["Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study."],"pmcid":["PMC9876601"],"funding_grant_id":["110828","110826","C12292/A11174","C1287/A10118","U01 CA179715","ELAN-Fond","U01 CA098758","NKI 2007-3839","U19 CA148065","R35 CA253187","U54 CA156733","R37 CA054281","106332","CA54281","R01 CA177150","P01 CA87969","U01 CA058860","P30-CA033572","P30 CA42014","Z01-CP010119","Z01 CP010119","NKI 2009-4363","R01-CA176785","C18281/A19169","002/RID/2018/19","CA128931","C1287/A16563","CA63464","UM1-CA164917","313404","14575/2470","MC_QA137853","U01 CA164920","NU58DP0063200","LVS39420","PERSPECTIVE project: GPH-129344","NIHR202411","1U19 CA148537","C1275/A15956","29019","MR/N003284/1","14505/2470","193387/H10","CRN-87521","P30 CA042014","C5047/A8384","PGfAR 0707-10031","PSR-SIIRI-701","396414","PI13/01162","Z99 CA999999","R01 CA132839","NU58DP006344","108419","HHSN261201800009C","C1275/C22524","70114178","U01-CA199277","C8221/A19170","HHSN261201800009I","C490/A16561","v203477/Z/16/Z","C1275/A11699","RUL 1997-1505","1074383","P50 CA116201","R01 CA063464","R01 CA054281","CA164973","MR/M012190/1","10CSA012E","K07 CA092044","UM1 CA186107","C1275/A19187","CA098758","R01-CA192393","HHSN261201800032C","CA132839","C8197/A16565","P30 CA071789","HHSN261201800032I","UM1 CA164920","P30-CA023100","CA177150","MC_UU_00011/6","R01 CA077398","MC_UU_00011/4","UM1 CA164917","MC_UU_00011/3","MC_UU_00011/1","634935","C490/A10124","110837","PI13/00061","Breast Cancer Campaign 2010PR62","PBZ_KBN_122/P05/2004","01KW9976/8","1000143","DDHK 2004-3124","R01 CA128931","Intramural Research Funds","C1281/A12014","АААА-А16-116020350032-1","1121258","17-29-06014","FIS Intrasalud (PI13/01136)","BBMRI-NL CP16","223175 (HEALTH-F2-2009-223175)","39346","209057","NF-SI-0512-10114","P50-CA116201","5NU58DP006344","U01 CA199277","P50 CA058223","VR 2017-00644","01GY1901","P30 CA068485","Z01-ES049033","1U19 CA148112","Z01-ES049030","ISCIII RETIC (RD06/0020)","CA92044","UM1 CA164973","DG-SANCO","01KW9975/5","FEDER-Innterconecta","P30 CA68485","R01-CA077398","R01 CA116167","RUS08/017","R01 CA163353","U01 CA063464","P30 CA023100","Z01-ES102245","193387/V50","294576","R01 CA100374","R01 CA192393","FAS0703856","70-2892-BR I","FEDER PI17/00918/Cofinanciado","01KH0402","IS-BRC-1215-20007","R01 CA058860","U19 CA148112","CA97396","C5047/A15007","Z01 ES044005","C5047/A10692","U19 CA148537","P01 CA087969","C1287/A10710","R01 CA128978","633784","29186","14136","R35-CA253187","16561","MC_PC_17228","713-241202","G1000143","Z01 ES049030","Z01 ES049033","P30 CA033572","P30 ES010126","R01 CA176785","EC11-192","W81XWH-10-1-0341","01KW0114","DDHK 2009-4318","C570/A16491","MCRF-18005","ERC-2011-294576","HHSN261201800016C","P30 CA008748","70492","HHSN261201800016I","17-44-020498","R01-CA100374","634935, 633784","01KW9977/0","FIS PI12/02125/Cofinanciado","U01-CA164920","R01-CA116167","CA58860","U01 CA164973","R01 CA097396","HHSN261201800015C","108253","HHSN261201800015I","UM1 CA176726","Breast Cancer Campaign 2013PR044","CA140286","R01 CA140286","G0401527","Z01-ES044005","CA128978"],"pubmed_authors":["Mavroudis D","Shah M","Taylor JA","Flyger H","Patel A","Dork T","Southey MC","Beane Freeman LE","Cross SS","Fritschi L","Clarke CL","Ahearn TU","Lubinski J","Tollenaar RAEM","Le Marchand L","Koutros S","Terry MB","Blomqvist C","Easton DF","Hoppe R","Untch M","Wolk A","Ambrosone CB","Fletcher O","Kitahara CM","Martinez ME","Becher H","Lynch BM","Gundert M","Rack B","Zheng W","Hall P","Harvie M","Hillemanns P","Hooning MJ","Peto J","Schmutzler RK","Brenner H","Truong T","Lush M","Canzian F","Hart SN","Dwek M","Lacey JV","Kaaks R","Hakansson N","Garcia-Saenz JA","Murphy RA","Bojesen SE","Plaseska-Karanfilska D","Engel C","Bogdanova NV","Bonanni B","Kurian AW","Daly MB","Rees-Punia E","Behrens S","John EM","Surowy H","Camp NJ","Manoochehri M","Ziogas A","Augustinsson A","Cox A","Gago-Dominguez M","Dixon-Suen SC","Eccles DM","Lindblom A","Jung A","Lambrechts D","Rennert G","Buys SS","Lewis SJ","Conroy DM","Dunning AM","Rennert HS","Garcia-Closas M","Kubelka-Sabit K","Andrulis IL","Goldberg MS","Kristensen VN","Olsson H","Offit K","Guenel P","Pharoah PDP","Weinberg CR","Wang Q","Swerdlow AJ","Keeman R","Evans DG","Couch FJ","Loibl S","Simard J","Breast Cancer Association Consortium","Tapper WJ","Bolla MK","Chanock SJ","Cessna MH","Milne RL","Chang-Claude J","Aronson KJ","Mulligan AM","Hahnen E","Howell A","Fasching PA","Olshan AF","Gabrielson M","Schmidt MK","Auvinen P","Nevanlinna H","Orr N","Michailidou K","Boyle T","Arndt V","Martin RM","Eriksson M","Kraft P","Haberle L","Saloustros E","English DR","Nevelsteen I","Anton-Culver H","Scott C","Vachon CM","Stone J","Presneau N","Hunter DJ","Joseph V","Hollestelle A","Menon U","Radice P","Yannoukakos D","Troester MA","Schwentner L","Giles GG","Beckmann MW","Devilee P","Tamimi RM","Haiman CA","Hopper J","Czene K","Margolin S","Shu XO","Newman WG","Romero A","Sandler DP","Dennis J","Investigators A","Eliassen AH","Wappenschmidt B","Bermisheva M","Castelao JE","Hamann U","Jakubowska A","Mannermaa A","Collaborators N","Janni W","Bruning T","Campa D"],"additional_accession":[]},"is_claimable":false,"name":"Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.","description":"<h4>Objectives</h4>Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.<h4>Methods</h4>We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (n<sub>snps</sub>=5) or sedentary time (n<sub>snps</sub>=6), or accelerometer-measured (n<sub>snps</sub>=1) or self-reported (n<sub>snps</sub>=5) vigorous physical activity.<h4>Results</h4>Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).<h4>Conclusion</h4>Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-28T11:32:24.103Z","creation":"2025-04-07T03:18:38.125Z"},"accession":"S-EPMC9876601","cross_references":{"pubmed":["36328784"],"doi":["10.1136/bjsports-2021-105132"]}}