biostudies-literatureJohansson MUniversität BielefeldDeutsche Forschungsgemeinschaft1404https://www.ebi.ac.uk/biostudies/studies/S-EPMC9876914biostudies-literatureUnknown13(1)Arabidopsis SENSITIVITY TO RED LIGHT REDUCED 1 (SRR1) delays the transition from vegetative to reproductive development in noninductive conditions. A second-site suppressor screen for novel genes that overcome early flowering of srr1-1 identified a range of suppressor of srr1-1 mutants flowering later than srr1-1 in short photoperiods. Here, we focus on mutants flowering with leaf numbers intermediate between srr1-1 and Col. Ssm67 overcomes srr1-1 early flowering independently of day-length and ambient temperature. Full-genome sequencing and linkage mapping identified a causative SNP in a gene encoding a Haloacid dehalogenase superfamily protein, named HAD-FAMILY REGULATOR OF DEVELOPMENT AND FLOWERING 1 (HDF1). Both, ssm67 and hdf1-1 show increased levels of FLC, indicating that HDF1 is a Scientific reportsHDF1, a novel flowering time regulator identified in a mutant suppressing sensitivity to red light reduced 1 early flowering.PMC9876914STA653/5-2JO1252/2-1Staiger DSteffen ALewinski MJohansson MKobi NfalseHDF1, a novel flowering time regulator identified in a mutant suppressing sensitivity to red light reduced 1 early flowering.Arabidopsis SENSITIVITY TO RED LIGHT REDUCED 1 (SRR1) delays the transition from vegetative to reproductive development in noninductive conditions. A second-site suppressor screen for novel genes that overcome early flowering of srr1-1 identified a range of suppressor of srr1-1 mutants flowering later than srr1-1 in short photoperiods. Here, we focus on mutants flowering with leaf numbers intermediate between srr1-1 and Col. Ssm67 overcomes srr1-1 early flowering independently of day-length and ambient temperature. Full-genome sequencing and linkage mapping identified a causative SNP in a gene encoding a Haloacid dehalogenase superfamily protein, named HAD-FAMILY REGULATOR OF DEVELOPMENT AND FLOWERING 1 (HDF1). Both, ssm67 and hdf1-1 show increased levels of FLC, indicating that HDF1 is a 2023-01-01T00:00:00Z2023 Jan2025-04-26T17:27:56.956Z2025-04-06T15:29:46.036ZS-EPMC98769143669743310.1038/s41598-023-28049-6