{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alexander LM"],"funding":["NCCIH NIH HHS","NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["197-211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9877134"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["For decades, bacteria have been exploited as vectors for vaccines and therapeutics. However, the bacterial arsenal used has historically been limited to a few strains. Advancements in immunology, combined with the development of genetic tools, have expanded our strategies and capabilities to engineer bacteria using various delivery strategies. Depending on the application, each delivery strategy requires specific considerations, optimization, and safety concerns. Here, we review various modes of therapeutic delivery used to target or vaccinate against a variety of ailments in preclinical models and in clinical trials. We highlight modes of bacteria-derived delivery best suited for different applications. Finally, we discuss current obstacles in bacteria-derived therapies and explore potent"],"journal":["Trends in microbiology"],"pubmed_title":["Modes of therapeutic delivery in synthetic microbiology."],"pmcid":["PMC9877134"],"funding_grant_id":["R01 GM135483","R01 AT011202","R21 AI146634"],"pubmed_authors":["Alexander LM","van Pijkeren JP"],"additional_accession":[]},"is_claimable":false,"name":"Modes of therapeutic delivery in synthetic microbiology.","description":"For decades, bacteria have been exploited as vectors for vaccines and therapeutics. However, the bacterial arsenal used has historically been limited to a few strains. Advancements in immunology, combined with the development of genetic tools, have expanded our strategies and capabilities to engineer bacteria using various delivery strategies. Depending on the application, each delivery strategy requires specific considerations, optimization, and safety concerns. Here, we review various modes of therapeutic delivery used to target or vaccinate against a variety of ailments in preclinical models and in clinical trials. We highlight modes of bacteria-derived delivery best suited for different applications. Finally, we discuss current obstacles in bacteria-derived therapies and explore potent","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-10T06:51:46.943Z","creation":"2025-02-19T03:25:44.424Z"},"accession":"S-EPMC9877134","cross_references":{"pubmed":["36220750"],"doi":["10.1016/j.tim.2022.09.003"]}}