{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(1)"],"submitter":["Ptaszek LM"],"pubmed_abstract":["<h4>Background</h4>High-power, short-duration (HPSD) radiofrequency ablation (RFA) may reduce ablation time. Concerns that catheter-mounted thermocouples (TCs) can underestimate tissue temperature, resulting in elevated risk of steam pop formation, potentially limit widespread adoption of HPSD ablation.<h4>Objective</h4>The purpose of this study was to compare the safety and efficacy of HPSD and low-power, long-duration (LPLD) RFA in the context of pulmonary vein isolation (PVI).<h4>Methods</h4>An open-irrigated ablation catheter with a contact force sensor and a flexible-tip electrode containing a TC at its distal end (TactiFlex<sup>TM</sup> Ablation Catheter, Sensor Enabled<sup>TM</sup>, Abbott) was used to isolate the left pulmonary veins (PVs) in 12 canines with HPSD RFA (50 W for 10 seconds) and LPLD RFA (30 W for a maximum of 60 seconds). PVI was assessed at 30 minutes and 28 ± 3 days postablation. Computed tomographic scans were performed to assess PV stenosis after RFA. Lesions were evaluated with histopathology.<h4>Results</h4>A total of 545 ablations were delivered: 252 with LPLD (0 steam pops) and 293 with HPSD RFA (2 steam pops) (<i>P</i> = .501). Ablation time required to achieve PVI was >3-fold shorter for HPSD than for LPLD RFA (<i>P</i> = .001). All 24 PVs were isolated 30 minutes after ablation, with 12/12 LPLD-ablated and 11/12 HPSD-ablated PVs still isolated at follow-up. Histopathology revealed transmural ablations for HPSD and LPLD RFA. No major adverse events occurred.<h4>Conclusion</h4>An investigational ablation catheter effectively delivered RFA lesions. Ablation time required to achieve PVI with HPSD with this catheter was >3-fold shorter than with LPLD RFA."],"journal":["Heart rhythm O2"],"pagination":["42-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9877396"],"repository":["biostudies-literature"],"pubmed_title":["Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter."],"pmcid":["PMC9877396"],"pubmed_authors":["Ptaszek LM","Jensen JA","Piccini JP","Pipenhagen C","Santangeli P","Ambrosius NM","Mahapatra S","Moon LB","Koruth J","Fish JM","Boudlali H","Ranjan R"],"additional_accession":[]},"is_claimable":false,"name":"Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter.","description":"<h4>Background</h4>High-power, short-duration (HPSD) radiofrequency ablation (RFA) may reduce ablation time. Concerns that catheter-mounted thermocouples (TCs) can underestimate tissue temperature, resulting in elevated risk of steam pop formation, potentially limit widespread adoption of HPSD ablation.<h4>Objective</h4>The purpose of this study was to compare the safety and efficacy of HPSD and low-power, long-duration (LPLD) RFA in the context of pulmonary vein isolation (PVI).<h4>Methods</h4>An open-irrigated ablation catheter with a contact force sensor and a flexible-tip electrode containing a TC at its distal end (TactiFlex<sup>TM</sup> Ablation Catheter, Sensor Enabled<sup>TM</sup>, Abbott) was used to isolate the left pulmonary veins (PVs) in 12 canines with HPSD RFA (50 W for 10 seconds) and LPLD RFA (30 W for a maximum of 60 seconds). PVI was assessed at 30 minutes and 28 ± 3 days postablation. Computed tomographic scans were performed to assess PV stenosis after RFA. Lesions were evaluated with histopathology.<h4>Results</h4>A total of 545 ablations were delivered: 252 with LPLD (0 steam pops) and 293 with HPSD RFA (2 steam pops) (<i>P</i> = .501). Ablation time required to achieve PVI was >3-fold shorter for HPSD than for LPLD RFA (<i>P</i> = .001). All 24 PVs were isolated 30 minutes after ablation, with 12/12 LPLD-ablated and 11/12 HPSD-ablated PVs still isolated at follow-up. Histopathology revealed transmural ablations for HPSD and LPLD RFA. No major adverse events occurred.<h4>Conclusion</h4>An investigational ablation catheter effectively delivered RFA lesions. Ablation time required to achieve PVI with HPSD with this catheter was >3-fold shorter than with LPLD RFA.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-27T00:51:25.553Z","creation":"2025-04-06T18:02:43.163Z"},"accession":"S-EPMC9877396","cross_references":{"pubmed":["36713045"],"doi":["10.1016/j.hroo.2022.10.009"]}}