biostudies-literatureUnknown4(1)Ptaszek LM<h4>Background</h4>High-power, short-duration (HPSD) radiofrequency ablation (RFA) may reduce ablation time. Concerns that catheter-mounted thermocouples (TCs) can underestimate tissue temperature, resulting in elevated risk of steam pop formation, potentially limit widespread adoption of HPSD ablation.<h4>Objective</h4>The purpose of this study was to compare the safety and efficacy of HPSD and low-power, long-duration (LPLD) RFA in the context of pulmonary vein isolation (PVI).<h4>Methods</h4>An open-irrigated ablation catheter with a contact force sensor and a flexible-tip electrode containing a TC at its distal end (TactiFlex^TM Ablation Catheter, Sensor Enabled^TM, Abbott) was used to isolate the left pulmonary veins (PVs) in 12 canines with HPSD RFA (50 W for 10 seconds) and LPLD RFA (30 W for a maximum of 60 seconds). PVI was assessed at 30 minutes and 28 ± 3 days postablation. Computed tomographic scans were performed to assess PV stenosis after RFA. Lesions were evaluated with histopathology.<h4>Results</h4>A total of 545 ablations were delivered: 252 with LPLD (0 steam pops) and 293 with HPSD RFA (2 steam pops) (<i>P</i> = .501). Ablation time required to achieve PVI was >3-fold shorter for HPSD than for LPLD RFA (<i>P</i> = .001). All 24 PVs were isolated 30 minutes after ablation, with 12/12 LPLD-ablated and 11/12 HPSD-ablated PVs still isolated at follow-up. Histopathology revealed transmural ablations for HPSD and LPLD RFA. No major adverse events occurred.<h4>Conclusion</h4>An investigational ablation catheter effectively delivered RFA lesions. Ablation time required to achieve PVI with HPSD with this catheter was >3-fold shorter than with LPLD RFA.Heart rhythm O242-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC9877396biostudies-literatureSafe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter.PMC9877396Ptaszek LMJensen JAPiccini JPPipenhagen CSantangeli PAmbrosius NMMahapatra SMoon LBKoruth JFish JMBoudlali HRanjan RfalseSafe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter.<h4>Background</h4>High-power, short-duration (HPSD) radiofrequency ablation (RFA) may reduce ablation time. Concerns that catheter-mounted thermocouples (TCs) can underestimate tissue temperature, resulting in elevated risk of steam pop formation, potentially limit widespread adoption of HPSD ablation.<h4>Objective</h4>The purpose of this study was to compare the safety and efficacy of HPSD and low-power, long-duration (LPLD) RFA in the context of pulmonary vein isolation (PVI).<h4>Methods</h4>An open-irrigated ablation catheter with a contact force sensor and a flexible-tip electrode containing a TC at its distal end (TactiFlex^TM Ablation Catheter, Sensor Enabled^TM, Abbott) was used to isolate the left pulmonary veins (PVs) in 12 canines with HPSD RFA (50 W for 10 seconds) and LPLD RFA (30 W for a maximum of 60 seconds). PVI was assessed at 30 minutes and 28 ± 3 days postablation. Computed tomographic scans were performed to assess PV stenosis after RFA. Lesions were evaluated with histopathology.<h4>Results</h4>A total of 545 ablations were delivered: 252 with LPLD (0 steam pops) and 293 with HPSD RFA (2 steam pops) (<i>P</i> = .501). Ablation time required to achieve PVI was >3-fold shorter for HPSD than for LPLD RFA (<i>P</i> = .001). All 24 PVs were isolated 30 minutes after ablation, with 12/12 LPLD-ablated and 11/12 HPSD-ablated PVs still isolated at follow-up. Histopathology revealed transmural ablations for HPSD and LPLD RFA. No major adverse events occurred.<h4>Conclusion</h4>An investigational ablation catheter effectively delivered RFA lesions. Ablation time required to achieve PVI with HPSD with this catheter was >3-fold shorter than with LPLD RFA.2023-01-01T00:00:00Z2023 Jan2025-04-27T00:51:25.553Z2025-04-06T18:02:43.163ZS-EPMC98773963671304510.1016/j.hroo.2022.10.009