{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["95(1)"],"submitter":["Berri F"],"pubmed_abstract":["We assessed relationships between early peripheral blood type I interferons (IFN) levels, clinical new early warning scores (NEWS), and clinical outcomes in hospitalized coronavirus disease-19 (COVID-19) adult patients. Early IFN-β levels were lower among patients who further required intensive care unit (ICU) admission than those measured in patients who did not require an ICU admission during severe acute respiratory syndrome coronavirus type 2 infection. IFN-β levels were inversely correlated with NEWS only in the subgroup of patients who further required ICU admission. To assess whether peripheral blood IFN-β levels could be a potential relevant biomarker to predict further need for ICU admission, we performed receiver operating characteristic (ROC) curve analyses that showed for all s"],"journal":["Journal of medical virology"],"pagination":["e28361"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9877952"],"repository":["biostudies-literature"],"pubmed_title":["Early plasma interferon-β levels as a predictive marker of COVID-19 severe clinical events in adult patients."],"pmcid":["PMC9877952"],"pubmed_authors":["Glenet M","N'Guyen Y","Lebreil AL","Reims COVID-19 Study Group","Bani-Sadr F","Pham BN","Berri F","Callon D","Heng L","Andreoletti L"],"additional_accession":[]},"is_claimable":false,"name":"Early plasma interferon-β levels as a predictive marker of COVID-19 severe clinical events in adult patients.","description":"We assessed relationships between early peripheral blood type I interferons (IFN) levels, clinical new early warning scores (NEWS), and clinical outcomes in hospitalized coronavirus disease-19 (COVID-19) adult patients. Early IFN-β levels were lower among patients who further required intensive care unit (ICU) admission than those measured in patients who did not require an ICU admission during severe acute respiratory syndrome coronavirus type 2 infection. IFN-β levels were inversely correlated with NEWS only in the subgroup of patients who further required ICU admission. To assess whether peripheral blood IFN-β levels could be a potential relevant biomarker to predict further need for ICU admission, we performed receiver operating characteristic (ROC) curve analyses that showed for all s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-18T14:05:43.126Z","creation":"2025-04-06T23:59:00.672Z"},"accession":"S-EPMC9877952","cross_references":{"pubmed":["36451263"],"doi":["10.1002/jmv.28361"]}}