biostudies-literatureUnknown27(2)Patouna AHoney is a complex mixture, containing ~180 compounds, produced by the <i>Apis melifera</i> bees, with promising antimicrobial and antioxidant properties. Nevertheless, the mechanisms through which honey exerts its effects remain under investigation. Plant antioxidants are found in honey and other bee products exhibiting a high bioactivity and molecular diversity. The aim of the present study was to estimate the antioxidant capacity of honey collected from areas in Greece by small‑scale producers by i) using <i>in vitro</i> cell free assays; and ii) by investigating the effects of honey varieties on the redox status of a liver cancer cell line (HepG2) using non‑cytotoxic concentrations. The findings of the present study will allow for the identification of Greek honeys with promising antioMolecular medicine reports54https://www.ebi.ac.uk/biostudies/studies/S-EPMC9879079biostudies-literatureEvaluation of the antioxidant potency of Greek honey from the Taygetos and Pindos mountains using a combination of cellular and molecular methods.PMC9879079Patouna AKouretas DVardakas PSkaperda ZSpandidos DAfalseEvaluation of the antioxidant potency of Greek honey from the Taygetos and Pindos mountains using a combination of cellular and molecular methods.Honey is a complex mixture, containing ~180 compounds, produced by the <i>Apis melifera</i> bees, with promising antimicrobial and antioxidant properties. Nevertheless, the mechanisms through which honey exerts its effects remain under investigation. Plant antioxidants are found in honey and other bee products exhibiting a high bioactivity and molecular diversity. The aim of the present study was to estimate the antioxidant capacity of honey collected from areas in Greece by small‑scale producers by i) using <i>in vitro</i> cell free assays; and ii) by investigating the effects of honey varieties on the redox status of a liver cancer cell line (HepG2) using non‑cytotoxic concentrations. The findings of the present study will allow for the identification of Greek honeys with promising antio2023-01-01T00:00:00Z2023 Feb2025-04-19T13:32:08.28Z2025-04-19T13:32:08.28ZS-EPMC98790793666093710.3892/mmr.2023.12941