{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huemer MT"],"funding":["Federal Ministry of Education and Research","German Federal Ministry of Education and Research"],"pagination":["afac324"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9879709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(1)"],"pubmed_abstract":["<h4>Background</h4>The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies.<h4>Objective</h4>Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample.<h4>Methods</h4>We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality.<h4>Results</h4>Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality.<h4>Conclusions</h4>Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed."],"journal":["Age and ageing"],"pubmed_title":["Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points."],"pmcid":["PMC9879709"],"funding_grant_id":["01ER1301A/B/C","01ET1003A","01ER1511D","01ET0713"],"pubmed_authors":["Castell S","Peters A","Jockel KH","Huemer MT","Stocker H","Schmidt B","Kaaks R","Ahrens W","Leitzmann M","Wirkner K","Schulze MB","Lieb W","Kluttig A","Teismann H","Schipf S","Michels KB","Mikolajczyk R","Karch A","Keil T","Gastell S","Drey M","Meinke-Franze C","Fischer B","Ebert N","Krist L","Schottker B","Thorand B","Kemmling Y","Moreno Velasquez I","Pischon T"],"additional_accession":[]},"is_claimable":false,"name":"Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points.","description":"<h4>Background</h4>The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies.<h4>Objective</h4>Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample.<h4>Methods</h4>We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19-75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65-93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality.<h4>Results</h4>Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality.<h4>Conclusions</h4>Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-07-09T12:24:31.347Z","creation":"2025-04-19T17:57:26.178Z"},"accession":"S-EPMC9879709","cross_references":{"pubmed":["36702514"],"doi":["10.1093/ageing/afac324"]}}