{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vivekanandan MM"],"funding":["Deutsche Forschungsgemeinschaft","Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts","Medical Research Council"],"pagination":["169-179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9879809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(1)"],"pubmed_abstract":["<h4>Background</h4>Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery.<h4>Study design and methods</h4>In this study, we analyzed the concentrations of selected plasma cytokines (i.e., IL-6, IP-10, IL-10, IL-22, IFNγ, GM-CSF, IL-8) and M. tuberculosis sputum burden in patients with tuberculosis (n = 76). Cytokine levels were compared to healthy contacts (n = 40) and changes under treatment were monitored (i.e., 6 and 16 weeks after treatment start). According to differences in M. tuberculosis sputu"],"journal":["Infection"],"pubmed_title":["Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients."],"pmcid":["PMC9879809"],"funding_grant_id":["JA 1479/9-1","MR/J01477X/1"],"pubmed_authors":["Abass MK","Mayatepek E","Yeboah A","Acheampong I","Jacobsen M","Debrah LB","Kumbel F","Phillips RO","Osei-Yeboah F","Arthur JF","Debrah A","Owusu DO","Seyfarth J","Aniagyei W","Adankwah E","Vivekanandan MM","Gawusu A","Lamptey MNK"],"additional_accession":[]},"is_claimable":false,"name":"Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients.","description":"<h4>Background</h4>Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery.<h4>Study design and methods</h4>In this study, we analyzed the concentrations of selected plasma cytokines (i.e., IL-6, IP-10, IL-10, IL-22, IFNγ, GM-CSF, IL-8) and M. tuberculosis sputum burden in patients with tuberculosis (n = 76). Cytokine levels were compared to healthy contacts (n = 40) and changes under treatment were monitored (i.e., 6 and 16 weeks after treatment start). According to differences in M. tuberculosis sputu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-19T03:50:11.677Z","creation":"2025-04-19T03:50:11.677Z"},"accession":"S-EPMC9879809","cross_references":{"pubmed":["35759173"],"doi":["10.1007/s15010-022-01870-3"]}}