biostudies-literatureVivekanandan MMDeutsche ForschungsgemeinschaftUniversitätsklinikum Düsseldorf. Anstalt öffentlichen RechtsMedical Research Council169-179https://www.ebi.ac.uk/biostudies/studies/S-EPMC9879809biostudies-literatureUnknown51(1)<h4>Background</h4>Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery.<h4>Study design and methods</h4>In this study, we analyzed the concentrations of selected plasma cytokines (i.e., IL-6, IP-10, IL-10, IL-22, IFNγ, GM-CSF, IL-8) and M. tuberculosis sputum burden in patients with tuberculosis (n = 76). Cytokine levels were compared to healthy contacts (n = 40) and changes under treatment were monitored (i.e., 6 and 16 weeks after treatment start). According to differences in M. tuberculosis sputuInfectionPlasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients.PMC9879809JA 1479/9-1MR/J01477X/1Abass MKMayatepek EYeboah AAcheampong IJacobsen MDebrah LBKumbel FPhillips ROOsei-Yeboah FArthur JFDebrah AOwusu DOSeyfarth JAniagyei WAdankwah EVivekanandan MMGawusu ALamptey MNKfalsePlasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients.<h4>Background</h4>Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery.<h4>Study design and methods</h4>In this study, we analyzed the concentrations of selected plasma cytokines (i.e., IL-6, IP-10, IL-10, IL-22, IFNγ, GM-CSF, IL-8) and M. tuberculosis sputum burden in patients with tuberculosis (n = 76). Cytokine levels were compared to healthy contacts (n = 40) and changes under treatment were monitored (i.e., 6 and 16 weeks after treatment start). According to differences in M. tuberculosis sputu2023-01-01T00:00:00Z2023 Feb2025-04-19T03:50:11.677Z2025-04-19T03:50:11.677ZS-EPMC98798093575917310.1007/s15010-022-01870-3