{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(1)"],"submitter":["Sahrmann JM"],"pubmed_abstract":["<h4>Objective</h4>To use interrupted time-series analyses to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare-associated infections (HAIs). We hypothesized that the pandemic would be associated with higher rates of HAIs after adjustment for confounders.<h4>Design</h4>We conducted a cross-sectional study of HAIs in 3 hospitals in Missouri from January 1, 2017, through August 31, 2020, using interrupted time-series analysis with 2 counterfactual scenarios.<h4>Setting</h4>The study was conducted at 1 large quaternary-care referral hospital and 2 community hospitals.<h4>Participants</h4>All adults ≥18 years of age hospitalized at a study hospital for ≥48 hours were included in the study.<h4>Results</h4>In total, 254,792 admissions for ≥48 hours occurred during the study period. The average age of these patients was 57.6 (±19.0) years, and 141,107 (55.6%) were female. At hospital 1, 78 CLABSIs, 33 CAUTIs, and 88 VAEs were documented during the pandemic period. Hospital 2 had 13 CLABSIs, 6 CAUTIs, and 17 VAEs. Hospital 3 recorded 11 CLABSIs, 8 CAUTIs, and 11 VAEs. Point estimates for hypothetical excess HAIs suggested an increase in all infection types across facilities, except for CLABSIs and CAUTIs at hospital 1 under the \"no pandemic\" scenario.<h4>Conclusions</h4>The COVID-19 era was associated with increases in CLABSIs, CAUTIs, and VAEs at 3 hospitals in Missouri, with variations in significance by hospital and infection type. Continued vigilance in maintaining optimal infection prevention practices to minimize HAIs is warranted."],"journal":["Antimicrobial stewardship & healthcare epidemiology : ASHE"],"pagination":["e14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9879893"],"repository":["biostudies-literature"],"pubmed_title":["Healthcare-associated infections (HAIs) during the coronavirus disease 2019 (COVID-19) pandemic: A time-series analysis."],"pmcid":["PMC9879893"],"pubmed_authors":["Dubberke ER","Kwon JH","Stwalley D","Michelson AP","McMullen KM","Nickel KB","Lyons PG","Gandra S","Olsen MA","Burnham JP","Sahrmann JM"],"additional_accession":[]},"is_claimable":false,"name":"Healthcare-associated infections (HAIs) during the coronavirus disease 2019 (COVID-19) pandemic: A time-series analysis.","description":"<h4>Objective</h4>To use interrupted time-series analyses to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare-associated infections (HAIs). We hypothesized that the pandemic would be associated with higher rates of HAIs after adjustment for confounders.<h4>Design</h4>We conducted a cross-sectional study of HAIs in 3 hospitals in Missouri from January 1, 2017, through August 31, 2020, using interrupted time-series analysis with 2 counterfactual scenarios.<h4>Setting</h4>The study was conducted at 1 large quaternary-care referral hospital and 2 community hospitals.<h4>Participants</h4>All adults ≥18 years of age hospitalized at a study hospital for ≥48 hours were included in the study.<h4>Results</h4>In total, 254,792 admissions for ≥48 hours occurred during the study period. The average age of these patients was 57.6 (±19.0) years, and 141,107 (55.6%) were female. At hospital 1, 78 CLABSIs, 33 CAUTIs, and 88 VAEs were documented during the pandemic period. Hospital 2 had 13 CLABSIs, 6 CAUTIs, and 17 VAEs. Hospital 3 recorded 11 CLABSIs, 8 CAUTIs, and 11 VAEs. Point estimates for hypothetical excess HAIs suggested an increase in all infection types across facilities, except for CLABSIs and CAUTIs at hospital 1 under the \"no pandemic\" scenario.<h4>Conclusions</h4>The COVID-19 era was associated with increases in CLABSIs, CAUTIs, and VAEs at 3 hospitals in Missouri, with variations in significance by hospital and infection type. Continued vigilance in maintaining optimal infection prevention practices to minimize HAIs is warranted.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T13:22:28.553Z","creation":"2025-04-06T14:10:44.854Z"},"accession":"S-EPMC9879893","cross_references":{"pubmed":["36714284"],"doi":["10.1017/ash.2022.361"]}}