biostudies-literatureUnknown7(1)Mayowski CThe COVID-19 pandemic had an immediate impact on the lives and work of early-career researchers. We leveraged a cluster-randomized trial and compared survey data collected over two timepoints to explore whether these impacts persisted. Although more than a year had passed, 74% of participants reported that their research was affected in multiple ways in <i>both</i> 2020 and 2021. These data suggest that the effects of the pandemic on early-career researchers may be prolonged. Our findings additionally serve as an impetus to identify and implement solutions to early-career challenges that undoubtedly existed before the pandemic, but which COVID-19 brought into the spotlight.Journal of clinical and translational sciencee7https://www.ebi.ac.uk/biostudies/studies/S-EPMC9879910biostudies-literatureContinued impact of COVID-19 pandemic on clinical and translational science early-career researchers.PMC9879910Meagher EAPatino-Sutton CWelch JLMayowski CWhite GERubio DMAlthouse ADThakar MSfalseContinued impact of COVID-19 pandemic on clinical and translational science early-career researchers.The COVID-19 pandemic had an immediate impact on the lives and work of early-career researchers. We leveraged a cluster-randomized trial and compared survey data collected over two timepoints to explore whether these impacts persisted. Although more than a year had passed, 74% of participants reported that their research was affected in multiple ways in <i>both</i> 2020 and 2021. These data suggest that the effects of the pandemic on early-career researchers may be prolonged. Our findings additionally serve as an impetus to identify and implement solutions to early-career challenges that undoubtedly existed before the pandemic, but which COVID-19 brought into the spotlight.2023-01-01T00:00:00Z20232025-04-18T20:47:39.15Z2025-04-07T08:48:36.489ZS-EPMC98799103675553310.1017/cts.2022.511