{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Di Rosa M"],"pubmed_abstract":["Colorectal Cancer (CRC) is one of the most common cancers accounting for 1.8 million new cases worldwide every year. Therefore, the identification of new potential therapeutic targets represents a continuous challenge to improve survival and quality of CRC patient's life. We performed a microarray analysis dataset consisting of colon biopsies of healthy subjects (HS) and CRC patients. These results were further confirmed in a clinical setting evaluating a series of CRC patients to assess the expression of Resistin-Like Beta (RETNLB) and to correlate it with their clinical data. Our results showed a significant reduction of RETNLB expression in CRC biopsies compared to the HS mucosa. Furthermore, such reduction was significantly associated with the TNM grade and patients' age. Furthermore, "],"journal":["Scientific reports"],"pagination":["1490"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9883247"],"repository":["biostudies-literature"],"pubmed_title":["Resistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients."],"pmcid":["PMC9883247"],"pubmed_authors":["Castrogiovanni P","Salomone F","Di Cataldo A","Caltabiano R","Imbesi R","Li Volti G","Lanteri R","Tibullo D","Broggi G","Raciti G","Di Rosa M"],"additional_accession":[]},"is_claimable":false,"name":"Resistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients.","description":"Colorectal Cancer (CRC) is one of the most common cancers accounting for 1.8 million new cases worldwide every year. Therefore, the identification of new potential therapeutic targets represents a continuous challenge to improve survival and quality of CRC patient's life. We performed a microarray analysis dataset consisting of colon biopsies of healthy subjects (HS) and CRC patients. These results were further confirmed in a clinical setting evaluating a series of CRC patients to assess the expression of Resistin-Like Beta (RETNLB) and to correlate it with their clinical data. Our results showed a significant reduction of RETNLB expression in CRC biopsies compared to the HS mucosa. Furthermore, such reduction was significantly associated with the TNM grade and patients' age. Furthermore, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-06-21T03:17:41.733Z","creation":"2026-06-21T03:11:27.072Z"},"accession":"S-EPMC9883247","cross_references":{"pubmed":["36707698"],"doi":["10.1038/s41598-023-28450-1"]}}